OBJECTIVES This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity. MATERIAL AND METHODS Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatin...

Rheum emodi or Himalayan rhubarb is a perennial herb belongs to family Polygonaceae. It has been used in various traditional systems as laxative, tonic, diuretic and to treat fever, cough, indigestion, menstrual disorder since antiquity. This paper consists of literature of Rheum emodi regarding its ethnobotany, folkloric uses, chemical properties and pharmacological studies. The material was c...

BACKGROUND/AIMS Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the protease-activated receptor 1. Parstatin was recently found to be cardioprotective against myocardial ischemia/reperfusion (IR) injury. In the present study, it was hypothesized that parstatin would protect the kidneys in acute renal failure. METHODS We investigated the effects of parstatin on th...

BACKGROUND Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) e...

Morphological study of rats kidneys after the simulation of rhabdomyolytic acute kidney injury by the single injection of 50% glycerol revealed the morphological changes in the renal cortex and medulla, which were manifested by the luminal obstruction of the cortical and medullary tubules with myoglobin casts, epithelial dystrophy and signs of coagulative necrosis. Use of glutathione improved t...

Renal disorders have always remained a major area of concern for physicians since a long time. It is the 9th leading cause of death in United States. Incidence of kidney diseases leading to kidney failure is increasing day by day. A large number of chemicals in common use are potential renal toxins. The use of herbal drugs for the prevention and treatment of various diseases is constantly devel...