One hundred fifty patients with potentially life-threatening digitalis toxicity were treated with digoxin-specific antibody fragments (Fab) purified from immunoglobulin G produced in sheep. The dose of Fab fragments was equal to the amount of digoxin or digitoxin in the patient's body as estimated from medical histories or determinations of serum digoxin or digitoxin concentrations. The younges...

Serial autocorrelation functions and histograms of R-R intervals in patients with atrial fibrillation, with and without digitalis, at rest and during exercise, were produced by a computer. At rest with and without digitalis the first and higher order coefficients did not differ from zero. During exercise (also with and without digitalis) only the first autocorrelation coefficient became slightl...

RECENTLY, we encountered an unusual response to digitalis. A patient with rheumatic valvular disease, congestive heart failure, and atrial fibrillation exhibited simultaneously evidence regarded by some as due to underdigitalization and by others as the result of overdigitalization. During mild exertion, the ventricular rate accelerated from 70 to 140 beats per minute with development of a puls...

The effect of digitalis in 21 patients with Wolff-Parkinson-White syndrome was anlayzed with respect to the ventricular response during atrial fibrillation and antegrade and retrograde refractory periods of accessory pathways. Digitalis shortened the cycle length of the most rapid ventricular response (shortest R-R) (i.e., increased the ventricle response) in 6/21 patients, increased the cycle ...

Digitalis is a genus of about 20 species of herbaceous perennials, shrubsand biennials commonly called foxgloves. The term digitalis is also used for drug preparations that contain cardiac glycosides, particularly the one called Digoxin, extracted from various plants of this genus. Cardiac glycosides cause arteriolar and venous constriction in a variety of mammalian species including human bein...

The investigation of ultradiluted (homeopathic) drugs is extremely interesting and challenging, and from that point of view this study shows novelty. A study of in vivo changes in heart rate of the Indian Bufo melanostictus caused by commercially available serially ultra-diluted and agitated extract of Digitalis purpurea has been tried in order to understand their pharmacological role. RR inter...

BACKGROUND Patients with anorexia nervosa exhibit higher levels of behaviours typically associated with autism-spectrum disorder (ASD), but the neural basis is unclear. We sought to determine whether elevated autistic traits in women with anorexia nervosa may be reflected in cortical morphology. METHODS We used voxel-based morphometry (VBM) to examine regional grey matter volumes in high-reso...

BACKGROUND During the years 1988-1993 the primary care incidence of anorexia nervosa in the UK remained stable, but the incidence of bulimia nervosa increased threefold. AIMS To determine whether the incidence of anorexia nervosa remained stable, and that of bulimia nervosa continued to increase, in the years 1994-2000. METHOD The General Practice Research Database was screened for new case...

Neural activation by digitalis has been shown to facilitate the development of cardiac arrhythmias and to mediate digitalis-induced increases in systemic and coronary resistance. Recent studies in our laboratory have implicated an area in the medulla within 2 inn of the obex as the locus for the neurally mediated arrhythmogenic properties of digitalis. To localize the site of digitalis-induced ...