Epidermolytic ichthyosis (EI) is a major form of congenital and characterized by erythroderma, marked scales, bulla, erosions at birth. EI recently classified as keratinopathic ichthyoses caused mainly heterozygous mutations in the KRT1 or KRT10 genes, encoding keratin (K) 1 K10, respectively. No effective treatment strategy for has been established yet. To investigate disease-specific markers ...