The proper formation of neuromuscular synapses requires ongoing synaptic activity that is translated into complex structural changes to produce functional synapses. One mechanism by which activity could be converted into these structural changes is through the regulated expression of specific synaptic regulatory factors. Here we demonstrate that blocking synaptic activity with curare reduces sy...

The purpose of this study was to determine the diagnostic test characteristics of serum neuregulin-1β (NRG-1β) for the detection of acute coronary syndrome (ACS). We recruited emergency department patients presenting with signs and symptoms prompting an evaluation for ACS. Serum troponin and neuregulin-1β levels were compared between those who had a final discharge diagnosis of myocardial infar...

3,773,919 A 11/1973 Boswell et al. 4,179,337 A 12/1979 Davis et al. 4,301,144 A 11/1981 Iwashita et al. 4,485,045 A 11/1984 Regen 4,496,689 A 1/1985 Mitra 4,544,545 A 10/1985 Ryan et al. 4,640,835 A 2/1987 Shimizu et al. 4,670,417 A 6/1987 Iwasaki et al. 4,791,192 A 12/1988 Nakagawa et al. 5,367,060 A 11/1994 Vandlen et al. 5,530,109 A 6/1996 Goodearl et al. 5,641,869 A 6/1997 Vandlen et al. 5,...