Extraosseous Ewing’s sarcoma/primitive neuroectodermal tumor is a rare malignant tumor with poor outcome. It is mostly reported in the second decade of life with equal in males and females. It is an aggressive tumor with unavoidable multiple recurrences and relatively poor prognosis. These tumors can be easily misdiagnosed for different tumors due to lack of established diagnostic pathological ...

Objective To investigate the clinicopathological feature, immunological phenotype, therapy and prognosis of primary renal primitive neuroectodermal tumor (primitive neuroectodermal tumor, PNET). Method To report diagnose and treat condition of a child with renal PNET and review relevant literature. Result The male patient aged 13 years old. Color-ultrasound found 3.5 cm × 3.0cm mass of left kid...

The translocation t(11;22) is a common chromosomal abnormality detected both in Ewing’s sarcoma and in primitive neuroectodermal tumor cells. The translocation results in an EWS-Fli1 fusion gene, made up of the 5 9 half of the EWS gene on chromosome 22 fused to the 3 9 half of the Fli1 gene on chromosome 11. Recent studies have evaluated possible roles of the fusion gene products. However, the ...

The HNK-1 antibody known to define a subpopulation of human lymphocytes with natural killer and killer cell activities was shown to detect a common neuroectodermal antigen. Most tumor lines and paraffin-embedded tumors and normal tissues of neuroectodermal origin were specifically stained by HNK-1. Lines and tissues of other derivations were negative except a trophoblastic tumor line and a perc...