Overview and Purpose This is the periodic update on the evaluation of the Nurse Family Partnership program in North Carolina focused on the priority health outcomes of women and infants. During this period, we refined our methodology to more precisely estimate the effect of NFP participation on the health of women and children. In this report, we will report the estimated effect of participatio...

Cdk5 exists in brain extracts in multiple forms, one of which is a macromolecular protein complex comprising Cdk5, neuron-specific Cdk5 activator p35nck5a and other protein components (Lee, K.-Y., Rosales, J. L., Tang, D., and Wang, J.H. (1996) J. Biol. Chem. 271, 1538-1543). The yeast two-hybrid system was employed to identify p35nck5a-interacting proteins from a human brain cDNA library. One ...

Changes in the neuronal content of neurofilament proteins occur in some neuropathological conditions, but little is known about the molecular mechanisms that control both the cell type specificity and the levels of expression of neurofilament genes. In addition to TATA and Sp1 elements, we report here the presence in the neurofilament light (NF-L) promoter region of other regulatory elements, n...

We have demonstrated previously that a wide array of stress signals induces O-GlcNAc transferase (OGT) expression and increases O-GlcNAcylation of many intracellular proteins, a response that is critical for cell survival. Here, we describe a mechanism by which glucose deprivation induces OGT expression and activity in Neuro-2a neuroblastoma cells. Glucose deprivation increases OGT mRNA and pro...

In triplet-triplet annihilation-based photon upconversion (TTA-UC), the utilization of near-infrared (NIR) light with a wavelength longer than 850 nm remains an outstanding issue. We realized this by employing metallonaphthalocyanines as triplet sensitizers; upon excitation of NIR light (856 nm), upconverted emission was observed in the visible range with remarkable photostability.

A system can only be improved if it is measured. In order to adequately measure a system, that system needs to be mapped and all key inter-nodal linkages, constraints and pathways recorded. Commercial supply chains demonstrate similar characteristics to other systems. Much has been written about mapping supply systems, where typically, the product or service is tracked from the originating sour...

Female C57BL6 mice were exposed to 0 or 800 ppm carbon disulfide (CS2), 6 h/d, 5 d/wk for 20 weeks. The neurologic function of all mice was assessed once at the end of exposures using a functional observational battery. General health effects included a decrease in body weight gain, piloerection, hunched body posture, and ptosis. Treatment-related effects included altered gait (uncoordinated pl...

The sera of patients with small cell carcinoma of the lung (SCCL) and an associated visual paraneoplastic syndrome (VPNS) have high titer immunoglobulins that react with retinal ganglion cells and with cloned lines of the SCCL. The immunoglobulins in the sera of two patients with SCCL and VPNS reacted with at least one common antigen shared by neural cells and cloned lines of the SCCL. The mole...