Paraneoplastic neurologic disorders are extremely rare in cancer patients and are most commonly associated with certain tumors, such as ovarian cancer, small cell lung cancer, and breast cancer. We report here a paraneoplastic neurological syndrome in a 53-year-old man with colonic adenocarcinoma with a solitary liver metastasis. His paraneoplastic syndrome was successfully treated by methylpre...

Neurosarcoidosis is a rare diagnosis, and it is also unusual for a patient with sarcoidosis to present solely with neurologic disease. However, CNS involvement can be the first manifestation of disease in 50% of patients. Thus, it is an important diagnostic consideration in patients presenting with ambiguous nervous-system lesions, particularly in the population most often affected by sarcoidos...

We describe the case of a young woman who was referred to a tertiary care center with unexplained subacute progressive encephalopathy preceded by long-standing severe headaches. Her extensive workup was remarkable for abnormal intracranial angiography suggestive of small- and medium-vessel vasculitis, persistently elevated protein in the cerebrospinal fluid and persistently high titers of antir...

What you are about to read is the first of a two part series about our new product Niadoxene Select. On the surface it appears to be deceptively simple with the active ingredients being just two nutrients – vitamin B3 in the form of niacinamide and vitamin B6 in the form of pyridoxal-5-phosphate (P5P, PLP). However, what I hope to convince you of in this two part series is that this very simple...

In a study of enteric fever, cerebellar ataxia was found to be the commonest neurological manifestation, second only to toxic delirium. Excluding toxic delirium (found in 25-30% of cases) neurologic deficit was noted in 5.0% of a series of 718 consecutive cases; 2.3% showed cerebellar ataxia, either as an isolated feature or in association with other lesions. The ataxia usually appeared in the ...

This clinical case report represents an interesting manifestation of a neurovascular condition that can be easily overlooked by the practicing healthcare provider. In the United States, a Hispanic patient of non-Asian descent presented with atypical symptoms of intractable headache and nausea with no evidence of neurologic deficits. Further diagnostic work-up was performed as the patient was no...

Sporadic inclusion body myositis (sIBM) usually manifests with painless weakness of the hand, finger and hip flexors. Absence of symptoms or signs, but mild hyper-CK-emia as the sole manifestation of IBM, has not been reported. We report the case of a 73-year-old male who presented with asymptomatic recurrent hyper-CK-emia ranging from 200 to 1324U/L (n<171U/L), since 10 years. Clinical neurolo...

BACKGROUND The authors explored the relationship between nitrous oxide use and neurologic and neuropsychological outcome in a population of patients likely to experience intraoperative cerebral ischemia: those who had temporary cerebral arterial occlusion during aneurysm clipping surgery. METHODS A post hoc analysis of a subset of the data from the Intraoperative Hypothermia for Aneurysm Surg...

Hereditary Haemorrhagic Telangiectasia (HHT), or Osler-Weber-Rendu syndrome is an uncommon autosomal dominant multi-organ condition of vascular dysplasias. We describe a 19 year old Indian female who presented with cerebral abscess secondary to paradoxical emboli from pulmonary arteriovenous malformations (PAVMs) associated with HHT. Cerebral, pulmonary, hepatic and gastrointestinal involvement...

BACKGROUND Late-onset GM2 gangliosidosis (LGG) is a rare disease that is often considered in the differential diagnosis of adolescents and young adults who present with multiple realms of neurologic dysfunction. Cognitive disturbances are common but have not been systematically studied. OBJECTIVE To determine the natural history of cognitive dysfunction in patients with LGG. DESIGN Case ser...