Five years ago we presented an investigation on the relative merits of malaria plus tryparsamide, and malaria only, as therapeutic agents for the treatment of neurosyphilis; and a detailed account of the changes in the cerebrospinal fluid after malaria therapy was also given at the same meeting. Since then the advent of penicillin has revolutionized the treatment of neurosyphilis. We are now pr...

The yardstick of failure in the treatment of early syphilis is the incidence of continued sero-resistance, of clinical and serological relapse, or, very occasionally, of asymptomatic neurosyphilis demonstrated by changes in the cerebrospinal fluid. Experience has taught us that, with careful observation, the great majority of failures can be detected during the first two years. This is now the ...

We report a case of a 46-year-old man presenting with a progressive cognitive decline, ataxic gait, urinary incontinence for 4 months and neuroimaging consistent with normal pressure hydrocephalus. The atypical presentation of a progressively worsening dysphasia and a right hemiparesis dismissed as a vascular event 1 month earlier associated with normal pressure hydrocephalus prompted further i...

With the advent of penicillin and other antibiotics, the incidence of syphilis in the West has largely declined (Martin, 1972). The classical forms of tabes dorsalis, G.P.I. and meningiovascular syphilis have become rarities (Ed. BMJ). This is replaced by atypical forms and in between forms of the disease (Hooshmand et al., 1972; Joyce-Clark et al., 1978 and Koffman, 1956). Despite being one of...

A 66-year-old man was admitted with visual impairment, functional disability, and worsening glycemic control. On admission, he had optic atrophy without diabetic retinopathy in both eyes, sensory impairment of the lower extremities, ataxia, and cognitive impairment. As both serum and cerebrospinal fluid tested positive for syphilis, he was diagnosed with neurosyphilis and treated with antibioti...

THE examination of cerebrospinal fluid in various diseased states has become a matter of routine investigation and at times yields information of great value in particular cases-for instance, the presence of a cellular content of over 3 per c.mm. leads to a suspicion of some infective process involving the central nervous system, and the preponderance of a mononuclear type of cell suggests the ...

Recent studies have shown that several long noncoding RNAs (lncRNAs) are involved in regulating the immune response to cope with pathogenic invasion. To date, the roles of lncRNAs in the CD4+ T cell response to Treponema pallidum (T. pallidum) infection in neurosyphilis patients remain unknown. The mRNA and lncRNA expression profiles of CD4+ T cells that were isolated from neurosyphilis patient...

PURPOSE To evaluate and describe the neuroimaging findings of patients with neurosyphilis. METHODS The neuroimaging studies of 35 patients with documented neurosyphilis were reviewed. Diagnosis was established in 34 patients with cerebrospinal fluid for a Venereal Disease Research Laboratory test, complemented by autopsy in 1 and brain biopsy in 1. All patients had reactive fluorescent trepon...

Introduction: Ocular syphilis is a rare manifestation of syphilis. manifestations vary and can occur at all stages the disease. Syphilis affect eye structures, main complaint blurred vision, accompanied by non-specific symptoms such as pain in eye, does not respond to steroids. Case: The male patient, 54 years old, presents with complaints both eyes slowly getting worse history sexual multi-par...