Erythropoietin (EPO) is a neurotrophic factor that could be developed as a new drug for brain disorders. However, EPO does not cross the blood-brain barrier (BBB). In the present study, human EPO was re-engineered by fusion to the carboxyl terminus of the heavy chain of a chimeric monoclonal antibody (MAb) to the human insulin receptor (HIR). The HIRMAb acts as a molecular Trojan horse to ferry...

Abstract Introduction Vaginal dryness is a frequent complaint, especially in post-menopausal women. The physiology underlying the production of vaginal lubrication response to arousing stimuli established; however, no current pharmacological agents successfully target mechanisms utilizing this physiology. Previous research from our lab has demonstrated that female methamphetamine (meth) users e...

Some children with autism spectrum disorders (ASD; 15% to 30% of patients) show a significant and persistent regression in speech and social function during early childhood. There are no established treatments for the regressive symptoms. However, there are some known causes of this type of regression, such as Rett syndrome and Landau-Kleffner syndrome (LKS). In LKS, steroids have been used as ...

Low-level light therapy (LLLT) using red to near-infrared light energy has gained attention in recent years as a new scientific approach with therapeutic applications in ophthalmology, neurology, and psychiatry. The ongoing therapeutic revolution spearheaded by LLLT is largely propelled by progress in the basic science fields of photobiology and bioenergetics. This paper describes the mechanism...

Background: TMS is increasingly used to treat major depression, but factors that predict better treatment outcomes remain unclear. We assessed the association between age and response given inconsistent reports in literature, as prior studies were limited by small sample size, heterogeneity, outdated parameters, lack of assessment deep TMS, an a priori hypothesis. hypothesized older would be as...

S. V. Ovsepian () · J. O. Dolly · V. B. O’Leary · G. W. Lawrence International Centre for Neurotherapeutics, Dublin City University, Dublin, Ireland Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ludwig-Maximilians-Universität München, München, Germany e-mail: [email protected] and [email protected] Abstract Quantal transmitter release from nerves is inhibited by all seve...

Advances in omics, in-vitro phenotypic assays, and medical informatics accelerate use of big data for predictive assessment of clinical efficacy and safety. We have integrated transcriptomic, proteomic and genomic data with clinical incidence of specific drug-induced adverse reaction to analyze and construct predictive modeling of drug safety. My talk will cover our systems pharmacology modelin...

The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer's disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates with higher therapeutic efficacy than single-targeting drugs. By following the multi-target approach, we designed and synthesized a novel class of dual acetylcholinesterase (AChE...