PURPOSE We aimed to test our primary hypothesis that the effects of methylprednisolone on bone marrow in chickens are age-sensitive and increase with prolonged treatment and our secondary hypothesis that the effects of methylprednisolone on bone marrow can have individual effects. METHODS Sixteen control (group A) and 29 methylprednisolone-treated (group B) chickens were categorised by age: p...

This study aimed to quantify new bone formation in the femurs of diabetic Wistar rats. Over an eight-week period, MTI-MP implants were evaluated in control rats and in diabetic rats. At several points during this period, various markers for bone deposit were introduced. The material was observed under fluorescent light microscopy. New bone formation in periosteal and cortical regions linked to ...

Increased mechanical loading of bone with the rat tibia four-point bending device stimulates bone formation on periosteal and endocortical surfaces. With long-term loading cell activity diminishes, and it has been reported that early gains in bone size may reverse. This study examined the time course for bone cellular and structural response after 6, 12, and 18 wk of loading at 1,200-1, 700 mic...

the gamma irradiation has been used for end sterilization of allograft bones and its effects with a 25 kgy dosage on the osteoinductive properties of demineralized bone allograft powder was studied. this work carried out using an experimental method in an animal model. in this study the demineralized bone allograft powder which had been sterilized and prepared with gamma irradiation in a 25 kgy...

Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of IP with new bone formation and an investigation into a possible role for bone morphogenic protein...

by Travis L. Turnbull Human cortical bone, like many engineering materials, is subject to damage and fracture, especially resulting from cyclic loading conditions routinely experienced by the load-bearing long bones. Unlike other materials, bone possesses a unique ability to repair damage and prevent or reduce fracture risk. However, in cases such as athletes and military recruits, the rate and...

It has been known for about seventy years that bone, in all vertebrates, contains uniquely high citrate levels. However, the role of citrate, its source, its regulation, and its implication in normal bone formation and in bone disorders have remained largely unknown. For the past thirty-five years, the relationship of citrate in bone has been a neglected area of attention and research. It has r...

PURPOSE The aim of this study was an experimental evaluation of the effectiveness of demineralized bone matrix (DBM) and collagenated heterologous bone graft (CHBG) used alone or in combination with platelet-rich fibrin on bone healing in sinus floor augmentation procedures. MATERIALS AND METHODS In this study, 36 New Zealand rabbits were used. The bilateral sinus elevation was performed, and...