A small molecule, hitherto called X, which is present in legume root nodules and ligates reversibly to the monomeric protein, leghemoglobin, with formation of a hemochrome structure, is identified as nicotinic acid. The binding constants at pH 5.3 are K = 7.3 x 10(5) M(-1) and K = 3.0 x 10(4) M(-1) for combination of nicotinic acid with ferric and ferrous leghemoglobin, respectively. This high ...

FOLLOWING the lead of Altschul, 1 a number of investigators have established that nicotinic acid depresses the serum cholesterol. A previous report indicated that inclusion of nieotinic acid in experimental diets fed to rabbits partially prevented the anticipated rise in serum cholesterol, prevented cholesterol deposition in the aorta and, to a lesser extent, cholesterol deposits in the liver. ...

Bordetella pertussis suppresses transcription of its virulence genes in response to specific environmental conditions, a response called modulation. The organism responds to high concentrations of SO4 and CIO4 ions, nicotinic acid, and nicotinic acid analogs in vitro; however, the in vivo modulator has not been identified. We investigated which chemical structures of the nicotinic acid molecule...

Aim. The aim of the research was to investigate induction Triticum aestivum L. non-specific tolerance by nicotinic acid hypoxia during flooding stress. Methods. Winter wheat plants cv. Ladyzhynka were grown in laboratory conditions and had been treated solution then stress started. hydrogen peroxide content leaves morphometric parameters measured experimental period. Results. It is shown that i...

The production of nicotinic acid and nicotinamide can be intensified by enzymatic conversion of 3-cyanopyridine. This fermentation process requires an economic and efficient separation method to compete with the synthetic process. In the present study, equilibrium data for the extraction of nicotinic acid using TOA dissolved in different diluents such as toluene and butyl acetate and n-dodecane...

The uptake and metabolism of nicotinic acid, nicotinamide, and quinolinic acid at physiological concentrations by perfused rat liver have been studied. At a level of 400 mpmoles per liver, nicotinic acid was a more effective precursor of NAD than was nicotinamide. Labeled NAD in the liver reached maximum levels 10 min after nicotinic acid was added to the perfusate. When nicotinamide was the su...

The biosynthetic pathway of diphosphopyridine nucleotide has been formulated through a study of yeast autolysates, erythrocytes, and liver homogenates. Two such pathways have been described by these procedures. Each system ultimately utilizes the enzyme diphosphopyridine nucleotide pyrophosphorylase. In the first pathway, the enzyme produces diphosphopyridine nucleotide directly by coupling ade...

Low HDL-cholesterol is common among patients with cardiovascular disease. Well-designed epidemiological studies carried out over the previous three decades have defined the prognostic significance of low HDL-cholesterol. Indeed, a recent evaluation of patients undergoing coronary angiography showed that factors related to HDL-cholesterol, but not to LDL-cholesterol, were primarily responsible f...

IN the previous paper [Kodicek, 1940] the cyanogen-p-aminoacetophenone method for the estimation of nicotinic acid [Harris & Raymond, 1939, 1, 2] was tested on certain biological materials, and the individual steps of the reaction were examined in detail in order to ascertain the most accurate conditions for the application of the method. The procedure finally adopted has been used for determin...

In a recent paper, Banerjee, Ghosh and Bhattacharya (1948) have developed a method using Koenig's (1904) basic reaction for the estimation of nicotinic acid in urine in the presence of sugar. It represents a simplification of' the earlier methods of Melnick and Field (1940), Swaminathan (1939), Harris and Raymond (1939) and several others. An interest in the study of urinary excretion of nicoti...