1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia 2 Department of Clinical Oral Biology (Pharmacology), Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur,...

Pathogenic bacterial infections have become a major health problem worldwide. New antimicrobial agents are urgently needed to overcome this problem. In this study, antibacterial activity of Nigella sativa seed extract against some pathogenic bacterial strains (Streptococcus pyogene, Pseudomonas aeruginosa, klebseilla pneumoniae and Proteus vulgaris) was evaluated. Methanol extract at the concen...

Nigella sativa (NS) seeds have been used for medicinal purposes for centuries both as herbs and its oil. In Islam it is regarded as one of the greatest forms of healing medicine included in the medicine of prophet Mohammed. Huge number of studies have been carried out in recent years on the pharmacological effects of these seeds and also the possible relationship with their constituents. A numb...

Nigella glandulifera seeds are used as a spice or remedy for the treatment of various inflammatory diseases. This study aimed to investigate analgesic (writhing test), anti-inflammatory (ear-induced edema, vascular permeability test), antioxidant, and antitumor activities of total saponins from this plant (TSN). TSN (6, 12, and 24 mg/kg) were exhibited analgesic and anti-inflammatory activities...

After the beginning of metal processing at the transition from the Neolithic to the Bronze Age, further knowledge of ore mining and smelting had spread from the Near East to central Europe. In the copper ore deposits of Schwaz, in the central part of the Alps, the oldest traces of copper mining derive from the early to middle Bronze Ages. Investigation of a middle to late Bronze Age (1410–920 c...

The toxic effects of the extracts of Allium sativum (Garlic) were evaluated against adults of Hyalomma marginatum rufipes and Rhipicephalus pulchellus using three types (Types A, B and C) of contact toxicity bioassays. A. sativum bulbs were extracted with acetone, ethanol and dichloromethane (DCM) solvents. Among these three solvents, it is the DCM extract of A. sativum that appears to have ant...

Allium sativum has been reported to have a lot of therapeutic potentials such as antihypertensive, antimicrobial and hypocholesterolemic. This study has investigated its effect on anti-tubercular drugs hepatotoxicity. Wistar albino rats were pretreated and co-administered orally with aqueous solution of Allium sativum. Eighteen rats were divided into six groups of three rats each. Group 1 were ...

OBJECTIVE In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. MATERIALS AND METHODS The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...

Leaf extracts of Cymbopogon citratus (lemon grass) and bulb extracts of Allium sativum (garlic) extracted with various solvents (ethanol, ethyl acetate and aqueous for Cymbopogon citratus, and ethyl acetate chloroform and aqueous for Allium sativum) were evaluated for antidermatophytic activity against Microsporum spp. isolated from different water samples. Out of a total of 60 water samples an...