نتایج جستجو برای: nitrone

تعداد نتایج: 356  

2012
Christopher J. Traynham Steve R. Roof Honglan Wang Robert A. Prosak Lifei Tang Serge Viatchenko-Karpinski Hsiang-Ting Ho Ira O. Racoma Dominic J. Catalano Xin Huang Yongbin Han Shang-U Kim Sandor Gyorke George E. Billman Frederick A. Villamena Mark T. Ziolo

Nitric oxide (NO) and superoxide (O(2) (-)) are important cardiac signaling molecules that regulate myocyte contraction. For appropriate regulation, NO and O(2) (.-) must exist at defined levels. Unfortunately, the NO and O(2) (.-) levels are altered in many cardiomyopathies (heart failure, ischemia, hypertrophy, etc.) leading to contractile dysfunction and adverse remodeling. Hence, rescuing t...

Journal: :E3S web of conferences 2023

One of the important properties reinforced composite polymer materials is their physico-chemical properties. Their structure plays an role in assessing materials. Research objectives - to study high-strength Experiments were carried out at 100 and 400-fold magnification optical microscope morphology structural changes various parts with a binder ED-20 nitrone fibers. IR spectroscopic studies al...

Journal: :Zeitschrift für Kristallographie - New Crystal Structures 2008

Journal: :Annals of the New York Academy of Sciences 2002
Robert A Floyd Kenneth Hensley Michael J Forster Judith A Kelleher-Anderson Paul L Wood

Specific nitrones have been used for more than 30 years in analytical chemistry and biochemistry to trap and stabilize free radicals for the purpose of their identification and characterization. PBN (alpha-phenyl-tert-butyl nitrone), one of the more widely used nitrones for this purpose, has been shown to have potent pharmacologic activities in models of a number of aging-related diseases, most...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
James J Ley Alexey Vigdorchik Ludmila Belayev Weizhao Zhao Raul Busto Larissa Khoutorova David A Becker Myron D Ginsberg

Stilbazulenyl nitrone (STAZN) is a potent lipophilic second-generation azulenyl nitrone antioxidant, which is highly neuroprotective in rodent models of cerebral ischemia and trauma. This study was conducted to establish whether the neuroprotection induced by STAZN persists with chronic survival and to characterize STAZN's pharmacokinetics. Physiologically regulated rats received a 2-h middle c...

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