BACKGROUND An essential criterion for control of acromegaly is normalization of IGF-I levels. Somatostatin analogues act to suppress IGF-I and GH levels. OBJECTIVE To assess the efficacy and safety of 48 weeks titrated dosing of lanreotide Autogel. DESIGN Open-label, multicentre, phase III, 48-week trial. METHODS Patients with active acromegaly (IGF-I levels > 1.3 times upper limit of age...

AbstractThe ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and their solubility were also evaluated. The...

AbstractThe ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and their solubility were also evaluated. The...

The choice titration procedure presents a subject with a repeated choice between a standard option that always provides the same reward and an adjusting option for which the reward schedule is adjusted based on the subject’s previous choices. The procedure is designed to determine the point of indifference between the two schedules which is then used to estimate a utility equivalence point betw...

In article, we have reported a thermodynamic based study of aqueous solvation benzoic acid (C6H5COOH) at 288 to 318 Kelvin temperature. At this temperature range the dissociation constant (Ka) into solvent has been determined by applying titration method against standard basic solution NaOH different ionic strength NaCl. Although, in observation, value Ka is being inversely proportional respect...

Gold nanoclusters protected by a monolayer of 4-hydroxythiophenol (HOPhSAu MPCs) were synthesized and characterized by various analytical techniques. The particles were found to be soluble in alkaline aqueous solutions, whereas at low pH, flocculation of particles started to occur. Acid/base titration of particle solutions indicated that the pKa of particle-bound phenol moieties was close to 10...