The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogues built from...

A novel approach is presented in this article for obtaining inverse mapping of thermodynamically Pareto-optimized ideal turbojet engines using group method of data handling (GMDH)-type neural networks and evolutionary algorithms (EAs). EAs are used in two different aspects. Firstly, multi-objective EAs (non–dominated sorting genetic algorithm-II) with a new diversity preserving mechanism are us...

We examine emission from a young protostellar object (YPO) with threedimensional ideal MHD simulations and three-dimensional non-local thermodynamic equilibrium (non-LTE) line transfer calculations, and show the first results. To calculate the emission field, we employed a snapshot result of an MHD simulation having young bipolar outflows and a dense protostellar disk (a young circumstellar dis...

It has been established recently that there is an interesting thermodynamic ‘‘equivalence’’ between noninteracting Bose and spinless Fermi gases in two dimensions, and between onedimensional Bose and Fermi systems with linear dispersion, both in the grand-canonical ensemble. These are known to be special cases of a larger class of equivalences of noninteracting systems having an energy-independ...

In this paper multi-objective genetic algorithms are employed for Pareto approach optimization of ideal Turboshaft engines. In the multi-objective optimization a number of conflicting objective functions are to be optimized simultaneously. The important objective functions that have been considered for optimization are specific thrust 0 ( / ) & F m , specific fuel consumption ( P S ), output sh...

We examine the behavior of the diffusion coefficient of the ST2 model of water over a broad region of the phase diagram via molecular dynamics simulations. The ST2 model has an accessible liquid-liquid transition between low-density and high-density phases, making the model an ideal candidate to explore the impacts of the liquid-liquid transition on dynamics. We locate characteristic dynamical ...