Background: Alopecia areata (AA) is the most common type of non-scarring inflammatory alopecia. Objectives: To determine which immune and metabolic pathways are disregulated by circulating miRNAs in patients with alopecia (AA). Methods: Disease status was classified as mild/moderate (<50% involvement < 1 yr duration) severe (=> yr, ≥50% SALT, AT or AU). We interrogated 754 on 26 naïve 5 control...

A 27-years-man presented with progressive and wide spread hair loss over scalp, axillae and pubic area for the last 3-4 years. A multitude of therapies did not benefit him and the initial hair loss over occipital area had progressed to involve the whole scalp and other body sites. His medical history was unremarkable and no other family member had similar problem. Cutaneous examination (Figs. 1...

Alopecia areata (AA) is a disease involving non-scarring hair loss determined by autoimmune disorders and inflammation. The disease affects hair on the scalp and/or other parts of the body. The AA occurs in people of all ages and affects 1-2% of humans. The purpose of this paper is to present the latest knowledge on the treatment of AA. The decision on the type of treatment depends on the type ...

There are numerous dermatoses which may cause cicatricial alopecia when localized on the scalp, such as chronic discoid lupus erythematosus (DLE), lichen planus, graft-versus-host disease, dermatomyositis, scleroderma, cicatricial pemphigoid, porphyria cutanea tarda, follicular mucinosis, perifolliculitis capitis abscedens, lichen sclerosus et atrophicus, necrobiosis lipoidica, sarcoidosis, etc...

Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...

Alopecia areata (AA) is a common form of non-scarring hair loss of scalp and/or body. Genetic predisposition, autoimmunity, and environmental factors play a major role in the etiopathogenesis of AA. Patchy AA is the most common form. Atopy and autoimmune thyroiditis are most common associated conditions. Peribulbar and intrabulbar lymphocytic inflammatory infiltrate resembling "swarm of bees" i...

Hereditary mucoepithelial dysplasia (HMD) is a rare autosomal dominant disorder characterized by mucoepithelial disruption of the skin, hair and mucous membranes. It results from defective gap junction formation and leads to non-scarring alopecia, mucosal erythema, perineal erythematous intertrigo, involvement of the conjunctival mucosa, and pulmonary disease. We present a case of severe respir...