نتایج جستجو برای: nonalcoholic steatohepatitis
تعداد نتایج: 13470 فیلتر نتایج به سال:
Nonalcoholic fatty liver disease is characterized by excess accumulation of lipids within parenchymal cells of the liver (ie, hepatocellular steatosis) in the absence of excessive ethanol consumption. Fatty liver disease is widely considered to be the hepatic manifestation of metabolic syndrome and is estimated to occur in more than 25% of the Western population.1 Nonalcoholic fatty liver disea...
BACKGROUND There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency. OBJECTIVE We sought to determine whether subjects with biopsy-proven NAFLD and evidence of an inadequate intake of choline had more severe histologic features. DESIGN We performed a cross-sectional analysis of 664 subject...
61 Received September 11, 2014; revised and accepted January 5, 2015. Published online January 17, 2015; doi: 10.1620/tjem.235.61. Correspondence: Atsushi Fujio, M.D., Ph.D., Division of Transplantation, Reconstruction, and Endoscopic Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-0872, Japan. e-mail: [email protected] Long-Term Survival with Grow...
The staging of hepatic fibrosis is a cornerstone of prognosis and assessment of disease progression in those with chronic liver diseases including nonalcoholic steatohepatitis (NASH). This is so because a histological assessment of fibrosis has been the only clinically applicable readout of such progression over the last century. The last ten years have, however, seen numerous changes that have...
In this study, we report the association of the rs738407, rs738409, and rs2896019 variants of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene with nonalcoholic steatohepatitis (NASH) (χ(2)=14.528, p=0.001; χ(2)=18.882, p=0.000; χ(2)=7.449, p=0.024, respectively) in 80 patients with NASH and 303 healthy controls. We genotyped the subjects using three polyme...
Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder of lipid metabolism that is associated with abnormally low serum levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B. It is an autosomal co-dominant disorder, and depending on zygosity, the clinical manifestations may vary from none to neurological, endocrine, hematological or liver dysfunction. Nonalcoholic...
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