Methods We performed a prospective observational study with a cohort of 60 septic patients admitted to the ICU. Demographic data, severity scales, organ failure and doses of noradrenalin were registered. TnThs analysis was performed at baseline and in the first 24 hours a transthoracic echocardiography was performed to assess the ejection fraction (Simpson), once a correct resuscitation had bee...

Arilalkilaminler β-feniletilamin, mve p-tiramin, triptamin, mve p-oktapamin, feniletanolamin ve sinefrin klasik amin nörotransmitterler olan noradrenalin, dopamin ve 5-hidroksitriptamin (5-HT, serotonin)’e oranla santral sinir sistemindeki mutlak konsantrasyonlarının düşük olması nedeniyle eser aminler olarak adlandırılmıştır. Düşük konsantrasyonlarda bulunmalarına rağmen bu aminler bir çok psi...

In previous papers (Buznikov, Chudakova & Zvezdina, 1964; Buznikov, Chudakova, Berdysheva & Vyazmina, 1968) we reported that fertilized eggs of the sea-urchin Strongylocentrotus dwbachiensis synthesized a number of neurohumours, such as serotonin (5-hydroxytryptamine, 5-HT), acetylcholine (ACh), adrenalin (A), noradrenalin (NA) and dopamine. Synthesis of 5-HT was also demonstrated in the fertil...

Prevalence, pathophysiology, diagnostic and therapeutic approaches of urinary incontinence are well studied in women, however studies on male urinary incontinence focus on incontinence following surgery of the bladder or prostate, predominantly incontinence after radical prostatectomy. Aging men suffer from incontinence; most frequently urge incontinence (Overactive bladder) nearly as often as ...

BACKGROUND AIMS Neural stem cells (NSC) derived from bone marrow stromal cells (BMSC) (BMSC-D-NSC) are remarkably versatile in response to environmental signals, which render them useful in the search for neurodegenerative disease treatments. METHODS We isolated NSC from rhesus monkey bone marrow (BM), transfected them with the human tyrosine hydroxylase (hTH) gene, and transplanted them into...

This article reviews the pharmacologic and clinical evidence supporting the use of antidepressant drugs for treating painful rheumatologic conditions. Clinical studies have shown that tricyclic antidepressants, even at low doses, have analgesic effects in rheumatologic conditions equivalent to those of serotonin and noradrenalin reuptake inhibitors, but are less well tolerated. Selective seroto...

Fibromylagia (FM) is a complex chronic condition usually presenting with symptoms of widespread pain and fatigue, as well as sleep and cognitive disorders. The diagnosis is made by exclusion of other diseases and according to the EULAR criteria. The treatment of the disease is multidisciplinary and associated with a better understanding of the disease pathophysiology. The most commonly used dru...

Pons ta tüp şeklinde bir anatomik şekle sahip olan locus coeruleus küçük yapısına rağmen nerdeyse tüm merkezi sinir sistemini (M.S.S’yi) etkilemektedir. Yaklaşık iki yüzyıl önce fark edilen coeruleus, noradrenalin kaynağı olup hücrelerinin içerdiği nöromelanin pigmentinden kaynaklı koyu mavi olarak görülmektedir. Bu nedenle, Latince’de (gökyüzü mavisi) isimlendirilmiştir. Ponsta bilateral yerle...

Introduction Autism is a eurodevelopmental disability that is usually diagnosed before age 3 years. The need to understand the causes of autism and the underlying pathophysiology has become more acute since the number of diagnosed cases has risen markedly. Several recent research studies lend support to the hypothesis that abnormalities involving the plasma Amino Acids profiles have been implic...