To investigate the role of telomerase in the multistep Colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small «1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2.0 cm) polyps, and ...

OBJECTIVES To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. DESIGN Prospective study. SETTING Tertiary academic institution. PATIENTS Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal contr...

PURPOSE The current paradigm suggests that the homeodomain transcription factor Cdx2, which directs the development and maintenance of the intestinal epithelium, is a tumor suppressor in the colon and rectum. Although a cardinal property of tumor suppressors is their inactivation during carcinogenesis, the expression of Cdx2 in colorectal tumors has not been compared with that in normal mucosa....

conclusions our data has provided baseline information about epidemiologic aspects of oral mucosal lesions which can be valuable in organized national program targeting on oral health and hygiene in the society. results the prevalence of mucosal lesions in our study was 19.4%. our data demonstrated higher prevalence of oral mucosal lesions in males and young adults (30-40 years). the most commo...

inflamed mucosa with no parasites. Sections from the mucosa of ileum and caecum and the rectal biopsy specimen, trypsinised and stained with antisera to immunoglobulins, kappa and lambda chains, and IgA secretor piece, using the immunoperoxidase method, showed similar numbers and distributions of positive lymphocytes to those in normal controls. Peripheral lymphocyte subpopulations showed norma...

Rat colorectal mucosa was examined during the course of carcinogenesis, induced by chronic administration of 1,2-dimethylhydrazine (DMH), for the presence and amount of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein. These two binding proteins are implicated in the action of vitamin A in normal and neoplastic tissue. Induced adenocarcinomas were found to cont...

We have previously shown an important role of the chloride channel ClC-2 in orchestrating repair of tight junctions in ischemia-injured mucosa. In this study, we examined the role of ClC-2 in regulating barrier function of normal murine intestinal mucosa. Ex vivo, ClC-2-/- ileal mucosa mounted in Ussing chambers had significantly higher transepithelial electrical resistance (TER) and reduced [(...

BACKGROUND Cytochrome P450 (CYP) enzymes in epithelial cells lining the alimentary tract play an important role in both the elimination and activation of (pro-)carcinogens. To estimate the role of cytochrome P450 in carcinogenesis of the colon, expression patterns and protein levels of four representative CYPs (CYP2C, CYP2E1, CYP3A4 and CYP3A5) were determined in colon mucosa of normal and aden...

background: oral lichen planus (olp) is a chronic immunologic disease. the etiology of olp is unknown, viral antigens (for example epstein-bar virus) have been proposed as etiologic agents. olp may get transformation to malignancy so re search on the presence of ebv in olp lesions seems to be necessary. the aim of this study was to ascertain if ebv acted as etiologic factor in pathogenesis of o...

The ultracytochemical localization of adenylate cyclase (AC) and guanylate cyclase B (GC-B) and C (GC-C) activity was studied after stimulation with pituitary adenylate cyclase activating peptide, C-type natriuretic peptide and guanylin, respectively, in normal human respiratory nasal mucosa and mucosa of nasal polyps. To demonstrate these enzymatic activities, we employed enzyme-ultracytochemi...