This study examined the effectiveness of resistance exercise as a countermeasure to non-weight-bearing-induced alterations in the absolute peak force, normalized peak force (force/fiber cross-sectional area), peak stiffness, and maximal shortening velocity (Vo) of single permeabilized type I soleus muscle fibers. Adult rats were subjected to the following treatments: normal weight bearing (WB),...

to doing this research daily interpolated temperature data from asfezari data base have been used. in order to recognition extreme cold days, the normalized temperature deviation index (ntdi) applied. then the index sorted according to extensive and severity and first 500 days selected for analysis. the geopotential height data extracted from www.esrl.noaa.gov data base. the thickness anomaly c...

Many applications of clustering require the use of normalized data, such as text or mass spectra mining. The spherical k-means algorithm [6], an adaptation of the traditional k-means algorithm, is highly useful for data of this kind because it produces normalized cluster centers. The k-medians clustering algorithm is also an important clustering tool because of its wellknown resistance to outli...

Many applications of clustering require the use of normalized data, such as text or mass spectra mining. The spherical K-means algorithm [6], an adaptation of the traditional K-means algorithm, is highly useful for data of this kind because it produces normalized cluster centers. The K-medians clustering algorithm is also an important clustering tool because of its wellknown resistance to outli...

We examined the pharmacokinetic behavior of 200 mg of ciprofloxacin administered intravenously to 32 volunteers whose renal function as measured by creatinine clearance ranged from 0 to 8.99 liters/h per 1.73 m2. Serum clearances (mean +/- standard deviation) were 26.8 +/- 5.7 and 15.4 +/- 4.3 liters/h per 1.73 m2 in normal and anephric volunteers, respectively. The half-life (mean +/- standard...

In sampling based hotspot detection, performance engineers sample the running program periodically and record the Instruction Pointer (IP) addresses at the sampling. Empirically, frequently sampled IP addresses are regarded as the hotspot of the program. The question of how well the sampled hotspot IP addresses match the real hotspot of the program is seldom studied by the researchers. In this ...

BACKGROUND In a phase 1 study, we investigated whether interferon beta reduced endothelial damage in patients with cardiac persistence of human parvovirus B19 (B19V) infection. METHODS AND RESULTS In vitro, B19V infected cultivated endothelial cells (ECs), which led to a reduction in their viability (P = .007). Interferon beta suppressed B19V replication by 63% (P = .008) in ECs and increased...

Let p∈ [1,∞]. Consider the projection of a uniform random vector from a suitably normalized `p ball in Rn onto an independent random vector from the unit sphere. We show that sequences of such random projections, when suitably normalized, satisfy a large deviation principle (LDP) as the dimension n goes to ∞, which can be viewed as an annealed LDP. We also establish a quenched LDP (conditioned ...