BACKGROUND AND PURPOSE The cost-effectiveness of dabigatran for stroke prevention in patients with atrial fibrillation and prior stroke or transient ischemic attack has not been directly assessed. METHODS A Markov decision model was constructed using data from the Randomized Evaluation of Long-Term Therapy (RE-LY) trial, other trials of warfarin therapy for atrial fibrillation, and the publis...

Break-apart fluorescence in situ hybridization (FISH) is the gold standard test for anaplastic lymphoma kinase (ALK) gene rearrangement. However, this methodology often is assumed to be expensive and potentially cost-prohibitive given the low prevalence of ALK-positive non-small cell lung cancer (NSCLC) cases. To more accurately estimate the cost of ALK testing by FISH, we developed a micro-cos...

Grid computing, which is characterized by largescale sharing and collaboration of dynamic resources, has quickly become a mainstream technology in distributed computing. In this article, we present a grid-based software testing framework, which takes advantage of the large-scale and cost-efficient computational grid resources as a software testing testbed to support automated large-scale and co...

The Genetic Resource Center (GRC) is a centralized process for requesting genetic testing that is not available within the province (Alberta, Canada). In order to assess potential cost savings associated with this process, all applications received by the GRC in 2010 were reviewed, and cost savings were recorded for statistical analysis. Seven areas of cost savings were identified: (i) negotiat...

Mission-critical system designers are turning towards Commercial Off-The-Shelf (COTS) software to reduce costs and shorten development time even though COTS software components may not specifically be designed for robust operation. (Systems are robust if they can function correctly despite exceptional inputs or stressful conditions.) Automated testing can assess component robustness without sac...

BACKGROUND The value of gene expression classifier (GEC) testing for cytologically indeterminate thyroid nodules lies in its negative predictive value, which is influenced by the prevalence of malignancy. We incorporated actual GEC test performance data from a tertiary referral center into a cost-effectiveness analysis of GEC testing. METHODS We evaluated consecutive patients who underwent GE...

In this paper, reconfiguration problem of distribution network has been investigated toimprove reliability and reduce power loss by placement of renewable energy sources; i.e. solarcell and wind turbine. For this, four reliability indices are considered in objective function;which are as follows: System Average Interruption Frequency Index (SAIFI), System AverageInterruption Duration Index (SAI...

AI161380 0 Transcribed sequence with weak similarity to protein sp:P39188 (H.sapiens) ALU1_HUMAN Alu subfamily J sequence contamination warning entry

BACKGROUND Homozygosity for UGT1A1*28/*28 has been reported to be associated with atazanavir-associated hyperbilirubinaemia and premature atazanavir discontinuation. We assessed the potential cost-effectiveness of UGT1A1 testing to inform the choice of an initial protease-inhibitor-containing regimen in antiretroviral therapy (ART)-naive individuals. METHODS We used the Cost-Effectiveness of ...