نتایج جستجو برای: npcs
تعداد نتایج: 1491 فیلتر نتایج به سال:
Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in neighboring NPCs. The molecular mechanism that coordinates Notch1 inactivation with initiation of neurogenesis remains elusive. Here, we provide evide...
BACKGROUND Spinal cord injury (SCI) is a debilitating condition characterized by a complex of neurological dysfunctions ranging from loss of sensation to partial or complete limb paralysis. Recently, we reported that intravenous administration of neural precursors physiologically releasing erythropoietin (namely Er-NPCs) enhances functional recovery in animals following contusive spinal cord in...
OBJECTIVE Mutations in the Spastic Paraplegia Gene11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal recessive (AR) complex hereditary spastic paraplegia (HSP) and juvenile onset amyotrophic lateral sclerosis (ALS5). When SPG11 is mutated, patients frequently present with spastic paraparesis, a thin corpus callosum, and cognitive impairment. We previously delineated a neu...
Aims: This study was aimed to determine whether ethanol exposure during early development altered neurogenesis in the brain of adult rats. Methods: Pregnant rats were given either ethanol-mixed or mannose-mixed (for control) rodent liquid diet ad libitum. Ethanol drinking continued during pregnancy and nursing. After weaning, the pups (ACo: pups from control mothers, AEo: pups from ethanol expo...
Ischemic stroke is a leading cause of human death and disability while clinical treatments are limited. The adult brain possesses endogenous regenerative activities that may benefit tissue repair after stroke. Trophic factors such as stromal cell-derived factor 1 alpha (SDF-1α) are upregulated in the ischemic brain, which promote endogenous regeneration. The regenerative response, however, is n...
We present a game mechanic called pseudo-visibility for games inhabited by non-player characters (NPCs) driven reinforcement learning (RL). NPCs are incentivized to pretend they cannot see pseudo-visible players: the training environment simulates an NPC determine how would act if player were invisible, and penalizes acting differently. thereby trained selectively ignore players, except when ju...
Polyphosphazene was synthesized by ultrasonic using 4,4-diaminodiphenyl ether and hexachlorocyclotriphosphazene (HCCP) as precursors. Next, it further carbonized functionalized to prepare the carboxylic-acid N, P co-doped carbon materials (NPCs-COOH). The structure of NPCs-COOH characterized FTIR, SEM XPS. sorption performance for U(VI) in solution were determined under diverse factors includin...
The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules are excluded unless chaperoned across by transport factors. Here, we suggest a ...
health workforce shortages in sub-saharan africa are widely recognized, particularly of physicians, leading the training and deployment of non-physician clinicians (npcs). the paper by eyal et al provides interesting and legitimate viewpoints on evolving role of physicians in context of decisive increase of npcss in sub-saharan africa. certainly, in short or mid-term, npcs will continue to be a...
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