Introduction Efficient delivery of rotigotine into the brain is crucial for obtaining maximum therapeutic efficacy for Parkinson's disease (PD). Therefore, in the present study, we prepared lactoferrin-modified rotigotine nanoparticles (Lf-R-NPs) and studied their biodistribution, pharmacodynamics, and neuroprotective effects following nose-to-brain delivery in the rat 6-hydroxydopamine model o...

A nanoparticle (NP) was developed to target choroidal neovascularization (CNV) via topical ocular administration. The NPs were prepared through conjugation of internalizing arginine-glycine-aspartic acid RGD (iRGD; Ac-CCRGDKGPDC) and transactivated transcription (TAT) (RKKRRQRRRC) peptide to polymerized ethylene glycol and lactic-co-glycolic acid. The iRGD sequence can specifically bind with in...

The Internet has played a major role in the distribution of New Psychoactive Substances (NPS), and crypto markets are increasingly used for the anonymous sale of drugs, including NPS. This study explores the availability of individual NPS and vendors on the crypto markets and considers whether crypto markets are a reliable platform for the sale of NPS. Data was collected from 22 crypto markets ...

because most contaminants in water create strong interactions with hydrophobic surfaces, there are usually problems such as flux decline and pore blocking in polyethylene (pe) membranes due to irreversible adsorption of foulants on their intrinsic hydrophobic surface. therefore, in this work, attempts were made to improve the properties of pe membranes in terms of water flux and membrane foulin...

OBJECTIVE Complexation was investigated as an approach to enhance the entrapment of the cationic neurotherapeutic drug, galantamine hydrobromide (GH) into cationic chitosan nanoparticles (CS-NPs) for Alzheimer's disease management intranasally. Biodegradable CS-NPs were selected due to their low production cost and simple preparation. The effects of complexation on CS-NPs physicochemical proper...

BACKGROUND The aim of this study is to evaluate the anticancer activity of vorinostat-incorporated nanoparticles (vorinostat-NPs) against HuCC-T1 human cholangiocarcinoma cells. Vorinostat-NPs were fabricated by a nanoprecipitation method using poly(DL-lactide-co-glycolide)/poly(ethylene glycol) copolymer. RESULTS Vorinostat-NPs exhibited spherical shapes with sizes <100 nm. Vorinostat-NPs ha...

Due to overexpression of glycyrrhetinic acid (GA) receptor in liver cancer cells, glycyrrhetinic acid modified recombinant human serum albumin (rHSA) nanoparticles for targeting liver tumor cells may result in increased therapeutic efficacy and decreased adverse effects of cancer therapy. In this study, doxorubicin (DOX) loaded and glycyrrhetinic acid modified recombinant human serum albumin na...

Environmental release of engineered nanoparticles (NPs) has been on the rise due to the increased use of NPs in commercial products. In addition, the fate of NPs in sewage treatment processes may play an important role in determining the environmental release pathway of NPs. In this study, we investigated the removal of engineered NPs (AgNPs, TiO2NPs, and SiO2NPs) using activated sludge by eval...

application of nanotechnology in medicinal and biological fields has attracted a great interest in the recent yeras. in this paper the cell membrane leakage induced by iron nanoparticles (fe-np) against pc12 cell line which is known as a model of nervous system cell line was investigated by the lactate dehydrogenase (ldh) test. therefore, pc12 cells were incubated with different concentration o...

objective(s): our previous studies have shown that mgo nanoparticles (mgo nps) could improve anxiety and reduce pain in animals. in this study, the effect of co administration mgo nps and vitamin c on anxiety like behavior and nociception in postpartum depression (ppd) model were investigated.materials and methods:  female mice (27 ± 3 g) were divided into groups: two control groups, ppd groups...