Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autoprotease. For efficient processing at the NS2/NS3 site, the NS2 cysteine protease...

Hepatitis C virus (HCV) non-structural 2 (NS2) encodes an essential protease activity responsible for processing at the NS2-NS3 junction which represents an attractive antiviral target. Attempts to inhibit the NS2 autoprotease with mechanism-based protease inhibitors and substrate peptides have had limited success. We report a series of epoxide-containing small molecules capable of blocking NS2...

Power consumption is the most important factor to evaluate performance of Wireless Sensor Networks. Most sensor network Medium Access Control (MAC) protocols operate based on a duty cycle mechanism. The asynchronous receiver-initiated MAC are popular due their relatively higher energy efficiency. However, recent advances harnessing benefits cooperative communication have become one solutions pr...

– The paper attempts to evolve a routing scheme with a view to improve the utilization capacity and enhance the life time of the Wireless Sensor Network (WSN). The focus charters to design a Cluster based Ad-hoc on Demand Distance Vector (CAODV) algorithm to facilitate the transfer of information in a composite network with both Code Division Multiple Access (CDMA) and non-CDMA nodes. It avails...

Wireless sensor networks, a distributed network of sensor nodes perform critical tasks in many application areas such as target tracking in military applications, detection of catastrophic events, environment monitoring, health applications etc. The routing protocols developed for these distributed sensor networks need to be energy efficient and scalable. To create a better understanding of the...

Currently in the literature, there are quite a number of multi-hop routing algorithms, some of which are subject to normalization. Routing protocols based on clustering provide an efficient method for extending the lifetime of a wireless sensor network. Except that much of the research focuses less on communication between the Cluster-Head (CH), the nodes and the base station, and gives even le...

To design of a wireless network, measurement of performances and selection of optimum path based on various parameters are the main strategies In this paper, performance analysis is carried out on “Optimized Link State Routing Protocol” OLSR routing protocol and measurement of performance analysis based on different simulation parameters under various simulation environments is presented. We de...

Vehicular ad hoc Networks (VANETs) can be designed in a way to organize road protection with no specific need for any fixed infrastructure. Accordingly, the movement of all vehicles planned according perceived information, and Quality Services Routing (QoSR) algorithms pressured its available options, paths, links, criteria reliability QoSR. Ensure that QoSR is aware environment network vehicle...

As part of the CESNET End-to-end performance project [1] we investigate enhancement of congestion control mechanisms providing better performance on fast long-distance networks. Network simulations end emulations are techniques that enable us to compare different alternatives and evaluate their performance under varying and well-defined network conditions, which would not be possible on real ne...

Wireless sensor networks which are used to monitor and control a specific area, are made of many small sensor nodes; they are compressed and spread in an environment. One of the most challenges in these types of networks is Energy limitation which has direct influence on sensor network lifetime. Unicast routing in wireless sensor networks is a way for data delivery to a receiver. In this paper ...