BACKGROUND Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined. FINDINGS Using the Siste...

Background—Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of cardiovascular disease. We therefore studied the duration of NSAID treatment and cardiovascul...

NSAIDs are nonsteroidal anti-inflammatory drugs, thus, they will provide analgesic,antipyretic, anti-inflammatory, antiplatelet effects. Severe poisoning and death because of acuteintoxication can occur by ingestions of more than 400 mg/kg. This cross-sectional retrospectivestudy was carried out in on all patients referred to Loghman Hakim Hospital from 2011 to 2016.Grou...

FOR PATIENTS WITH MUSCULOskeletal disorders, convent ional nonsteroidal anti inflammatory drugs (NSAIDs) are a mainstay of clinical care. Wellestablished limitations of NSAID therapy, however, include the risk of developing significant injury to the upper gastrointestinal (GI) tract. The annualized incidence rate of symptomatic GI ulcers and ulcer complications in NSAID users ranges from 2% to ...

INTRODUCTION Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently associated with community-acquired acute kidney injury (AKI), a strong risk factor for development and progression of chronic kidney disease. Using access to prescription medication profiles, pharmacists can identify patients at high risk for NSAID-induced AKI. The primary objective of this analysis was to evaluate the ef...

BACKGROUND about one fourth of patients with chronic idiopathic urticaria (CIU) experience flares of hives after taking chemically unrelated nonsteroidal anti-inflammatory drugs (NSAID). The reasons for such intolerance are still elusive. OBJECTIVE this study aimed to investigate NSAID intolerance in patients with CIU in view of the in vivo and in vitro histamine releasing activity of their s...

NSAIDs are widely used in the treatment of inflammatory diseases as well as of tendon diseases associated with pain in sports and labor. However, the effect of NSAID intake, and thus blockade of PGE(2) production, on the tendon tissue adaptation is unknown. The purpose of the present study was to elucidate the possible effects of NSAID intake on healthy tendon collagen turnover in relation to a...

OBJECTIVE To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR). DESIGN Cohort study. SETTING A healthcare database containing the electronic GP medical records of over 1.5 million patients throughout the Netherlands. ...

METHODS. All subjects completed a questionnaire detailing the implicated NSAID, their reaction history, and any individual risk factors. Subjects were stratified into 2 separate groups: those who reacted to a single NSAID and those who reacted to multiple NSAIDs. Based on a diagnostic algorithm, those with a positive result on skin prick test (SPT) to a single NSAID (n 5 1) were labeled as NSAI...

Findings from previous epidemiological studies are inconclusive, though they suggest nonsteroidal antiinflammatory drug (NSAID) use is associated with a reduction in breast cancer risk. In addition, animal studies report that NSAIDs inhibit mammary tumor development. The association between NSAID use and breast cancer risk was evaluated using a case-control study design. Cases were a random sam...