BACKGROUND Nipple-sparing mastectomy (NSM) has gained popularity for breast cancer treatment and prevention. There are limited data about long-term oncologic safety of this procedure. STUDY DESIGN We reviewed oncologic outcomes of consecutive therapeutic NSM at a single institution. Nipple-sparing mastectomy was offered to patients with no radiologic or clinical evidence of nipple involvement...

In the paper a Nonlinear Set Membership (NSM) prediction method is applied to forecast tropospheric pollution. The NSM method does not require the choice of the functional form of the model used for prediction but only assumes a regularity condition on the regression function defining the model. In this way, the complexity/accuracy problems deriving from the proper choice of a suitable parametr...

SUMMARY Nipple-sparing mastectomy (NSM) is gaining acceptance as an oncologically sound and cosmetically superior mastectomy technique. Debate exists over the management of positive margins near the nipple-areola complex. This case report presents a novel approach to the management of margin-positive ductal carcinoma in situ in NSM. A 50-year-old white female with invasive ductal carcinoma unde...

BACKGROUND Nipple-sparing mastectomy (NSM), understood as an oncologically valid procedure, is relatively new, and is an evolution of traditional mastectomy, particularly in relation to breast-conserving surgery. The anterior perforating branches are responsible for the cutaneous vascularization of the breast skin, and their preservation is a fundamental step to avoid possible postoperative nec...

Fiber-reinforced composite (FRP) materials have gained an increasing success, mostly for strengthening, retrofitting and repair of existing historic masonry structures and may cause a significant enhancement of the mechanical properties of the reinforced members. This article summarizes the results of previous experimental activities aimed at investigating the effectiveness of GFRP (Glass Fiber...

Activation of the Notch signaling pathway segregates the non-skeletogenic mesoderm (NSM) from the endomesoderm during sea urchin embryo development. Subsequently, Notch signaling helps specify the four subpopulations of NSM, and influences endoderm specification. To gain further insight into how the Notch signaling pathway is regulated during these cell specification events, we identified a sea...

The well-known regulative properties of the sea urchin embryo, coupled with the recent elucidation of gene regulatory networks (GRNs) that underlie cell specification, make this a valuable experimental model for analyzing developmental plasticity. In the sea urchin, the primary mesenchyme cell (PMC) GRN controls the development of the embryonic skeleton. Remarkably, experimental manipulations r...

See related article, pages 1680–1685. Neurogenic stunned myocardium (NSM) is reversible cardiac dysfunction, typically after subarachnoid hemorrhage (SAH).1,2 The most likely pathophysiology of NSM is a catecholamine surge that leads to transient ventricular dysfunction. The pathophysiology is probably similar to Tako-Tsubo cardiomyopathy3 and cardiac dysfunction caused by fright.4 SAH presents...

This paper investigates experimentally and analytically the torsion behavior of steel fibered high strength self compacting concrete beams reinforced by GFRP bars. Steel fibered high strength self compacting concrete (SFHSSCC) and GFRP bars became in the recent decades a very important materials in the structural engineering field. The use of GFRP bars to replace steel bars has emerged as one o...

The Tsc2 product, tuberin, negatively regulates the mTOR pathway. We have exploited the Eker (Tsc2-mutant) rat system to analyse various Tsc2 mutations. Here, we focus on the N525S-Tsc2 variant (NSM), which is known to cause distinct symptoms in patients even though normal suppression of mTOR is observed. Unexpectedly, we were repeatedly unable to generate viable rats carrying the NSM transgene...