The development of ▶ single-molecule spectroscopy has allowed for the investigation of a variety of biological questions previously inaccessible by ensemble techniques. The strength of single-molecule tools comes from the high-resolution data extracted from such experiments. Proper interpretation of these data requires efficient, unbiased analysis routines that are able to distinguish relevant ...

The ability to select a discrete region within the body for signal acquisition is a fundamental requirement of in vivo NMR spectroscopy. Ideally, it should be possible to tailor the selected volume to coincide exactly with the lesion or tissue of interest, without loss of signal from within this volume or contamination with extraneous signals. Many techniques have been developed over the past 2...

Exertional fatigue is a major limiting symptom in patients with heart failure. To investigate the metabolic basis of this fatigue, we used gated nuclear magnetic resonance spectroscopy to compare inorganic phosphate (P), phosphocreatine (PCr) and pH levels, and fatigue (1 to 4+) during mild forearm exercise in eight normal men and nine men with heart failure. Wrist flexion every 5 sec for 7 min...

Study of the nuclear magnetic resonance spectra of glyoxaldihydrazone in dimethylsulfoxide and deuterochlorofonn leads to the conclusion that this compound exists predominantly in non-chelate structure

This article reviews the principles and methods of nuclear magnetic resonance spectroscopy, and gives examples of applications carried out at our Facility, which illustrate the capabilities of the technique. Handbook of instrumental techniques from CCiTUB Nuclear Magnetic Resonance 1 ChT.4