نتایج جستجو برای: nucleotide polymorphisms

تعداد نتایج: 172638  

2016
Zhi Xu Gavin P. Reynolds Yonggui Yuan Yanyan Shi Mengjia Pu Zhijun Zhang

BACKGROUND Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminer...

Journal: :Hypertension 2007
Kristin J Meyers Thomas H Mosley Ervin Fox Eric Boerwinkle Donna K Arnett Richard B Devereux Sharon L R Kardia

Echocardiographic measures of cardiac target organ damage, including left ventricular mass and relative wall thickness, are powerful predictors of heart disease morbidity and mortality. The aim of this study is to investigate whether single nucleotide polymorphisms in candidate genes for hypertension and heart disease have effects on quantitative measures of hypertensive cardiac target organ da...

Journal: :Animal genetics 2013
J D Kurushima M J Lipinski B Gandolfi L Froenicke J C Grahn R A Grahn L A Lyons

Both cat breeders and the lay public have interests in the origins of their pets, not only in the genetic identity of the purebred individuals, but also in the historical origins of common household cats. The cat fancy is a relatively new institution with over 85% of its 40-50 breeds arising only in the past 75 years, primarily through selection on single-gene aesthetic traits. The short, yet i...

2014
Xia Pu Liewei Wang Joe Y. Chang Michelle A.T. Hildebrandt Yuanqing Ye Charles Lu Heath D. Skinner Nifang Niu Gregory D. Jenkins Ritsuko Komaki John D. Minna Jack A. Roth Richard M. Weinshilboum Xifeng Wu

Definitive radiotherapy improves locoregional control and survival in inoperable non-small cell lung cancer patients. However, radiation-induced toxicities (pneumonitis/esophagitis) are common dose-limiting inflammatory conditions. We therefore conducted a pathway-based analysis to identify inflammation-related single-nucleotide polymorphisms associated with radiation-induced pneumonitis or eso...

ژورنال: Medical Laboratory Journal 2018
Kheiri, Semira, Safarzad, Mahdieh, Shariati, Mohammad, Sohrabi , Hoda,

ABSTRACT             Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders. A computational-based analysis has been done to evaluate the phenotypic effect of no...

اسمعیلی زاده کشکوئیه, علی, خدابخش زاده, رسول, محمدآبادی, محمدرضا, مرادی شهربابک, حسین,

GDF9 gene is one of the most important effective factors on litter size in sheep. Thus, the aim of the present study was to detect single nucleotide polymorphisms (SNPs) available in exon 2 of GDF9 gene in pure and crossbred of Pakistani sheep using PCR-SSCP. Hence, blood samples were collected from 30 Pakistani sheep, 17 crossbred sheep (Pakistani rams × Lori-Bakhtiari) and 7 crossbred sheep (...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Yanhong Liu Michael E Scheurer Randa El-Zein Yumei Cao Kim-Anh Do Mark Gilbert Kenneth D Aldape Qingyi Wei Carol Etzel Melissa L Bondy

It is generally accepted that glioma develops through accumulation of genetic alterations. We hypothesized that polymorphisms of candidate genes involved in the DNA repair pathways may contribute to susceptibility to glioma. To address this possibility, we conducted a study on 373 Caucasian glioma cases and 365 cancer-free Caucasian controls to assess associations between glioma risk and 18 fun...

Primary ovarian insufficiency (POI) can be a devastating disease impacting women below the age of forty. This involves a major decrease in the amount and quality of oocytes, or ovarian reserve in a woman. The distribution of single-nucleotide polymorphisms, rs10407022 and rs3741664, in Iraqi people and its association with primary ovarian insufficiency is the main objective of this study. The m...

2017
Yoshiji Yamada Jun Sakuma Ichiro Takeuchi Yoshiki Yasukochi Kimihiko Kato Mitsutoshi Oguri Tetsuo Fujimaki Hideki Horibe Masaaki Muramatsu Motoji Sawabe Yoshinori Fujiwara Yu Taniguchi Shuichi Obuchi Hisashi Kawai Shoji Shinkai Seijiro Mori Tomio Arai Masashi Tanaka

We have performed exome-wide association studies to identify genetic variants that influence renal function-related traits or confer susceptibility to chronic kidney disease or hyperuricemia in Japanese. Exome-wide association studies for estimated glomerular filtration rate and the serum concentration of creatinine were performed with 12,565 individuals, that for the serum concentration of uri...

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