PURPOSE To investigate the compensation of secretory mucins with membranous mucins in mice with goblet cell deficiency. METHODS A transgenic mouse model in which conjunctival goblet cells were targeted was generated, and the expression of mucins was evaluated through the toxicity of diphtheria toxin A driven by a human mucin, MUC5AC, promoter. Immunohistochemical staining, in situ hybridizati...

We have determined the potential of exoproducts from pathogenic bacteria to stimulate the release of high molecular weight mucins from goblet cells of airway epithelium in a rabbit tracheal explant system. Culture supernatants from proteolytic strains of Pseudomonas aeruginosa and Serratia marcescens, but not supernatants from a number of non-proteolytic strains, released mucins from goblet cel...

Asian seabass (Lates calcarifer) is a food fish of increasing aquaculture importance. In order to improve our understanding on the digestive system and feeding of this species, morphological and histological features of the gut were studied. Morphologically, the Asian seabass gut is defined by a short and muscular esophagus, well-developed stomach and comparatively short intestine. Mucous secre...

Jones, R., Baetjer, A. M., and Reid, L. (1971). Brit. J. industr. Med., 28, 369-373. Effect of extremes of temperature and humidity on the goblet cell count in the rat airway epithelium. To investigate the effect of environmental temperature and humidity on the goblet cells in the rat airway epithelium, eight animals were exposed for four to five weeks to each of the following conditions: norma...

CONTEXT Barrett's esophagus is characterized by the presence of goblet cells. However, when alcian-blue is utilized, another type of cells, called columnar blue cells, is frequently present in the distal esophagus of patients with endoscopic evidence of Barrett's esophagus. Cytokeratin 7 and 20 immunoreactivity has been previously studied in areas of intestinal metaplasia at the esophagogastric...

The conjunctiva is a mucous membrane that covers the sclera and lines the inside of the eyelids. Throughout the conjunctiva are goblet cells that secrete mucins to protect the eye. Chronic inflammatory diseases such as allergic conjunctivitis and early dry eye lead to increased goblet cell mucin secretion into tears and ocular surface disease. The purpose of this study was to determine the acti...

the histology of digestive tract of caspian roach (rutilus rutilus caspicus) were studied for 53 days from hatching to fingerling size at the natural habitat of the larval stage. ages 1, 4, 10, 18, 28, 39 and 53 days after hatching (dah) were selected for the histological studies. after sampling and fixation with 10 percent formalin the histological process were conduct. the newly hatched larva...

PURPOSE To determine the cell kinetic properties of epithelial cells from various zones of the conjunctiva. METHODS The morphology and cell kinetics of bulbar, fornical, and palpebral conjunctival epithelium were studied in neonatal and adult SENCAR mice. To examine the proliferative rate of the conjunctival epithelium, a single administration of tritiated thymidine (3H-TdR) was used to detec...