We now think of classical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell origin, the malignant Hodgkin and Reed-Sternberg (HRS) cells have lost most of the superficial trappings of B cells and therefore have been hidden from investigators' lenses for decades, prompting a...

495 The complexity of the Discrete Fourier Transform (OFT) is studied with respect to a new model of computation appropriate to VLSI technology. This model focuses on two key parameters, the amount of silicon area and time required to implement a OFT on a single chip. Lower bounds on area (A) and time (T) are related to the number of points (N) in the OFT: AT2 > N2/16. This inequality holds for...

Multi-Core ECUs ermöglichen eine Vielzahl neuartiger Softwareund Systemarchitekturen, fordern Architekten jedoch auch viele grundlegende Entscheidungen ab, die oft weichenstellend für die spätere Implementierung sind. Diese Entscheidungen sind oft schwierig zu revidieren, müssen jedoch oft basierend auf Entscheidungen getroffen werden, da es nicht möglich ist deren Auswirkungen frühzeitig zu un...

In order to explain how crimes are carried out, and why at a particular place time against specific target, crime studies increasingly harness theory from behavioural ecology, in Optimal Foraging Theory (OFT). However, an overview of their main findings does not exist. Given the growing focus on OFT as framework for structuring research, this article we review extant OFT-inspired empirical rese...

RATIONALE The genes encoding fibroblast growth factor (FGF) 8 and 10 are expressed in the anterior part of the second heart field that constitutes a population of cardiac progenitor cells contributing to the arterial pole of the heart. Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do no...

Much of the heart, including the atria, right ventricle and outflow tract (OFT) is derived from a progenitor cell population termed the second heart field (SHF) that contributes progressively to the embryonic heart during cardiac looping. Several studies have revealed anterior-posterior patterning of the SHF, since the anterior region (anterior heart field) contributes to right ventricular and ...