نتایج جستجو برای: oligodendrogliomas
تعداد نتایج: 585 فیلتر نتایج به سال:
Pathological differentiation of oligodendroglioma and mixed oligoastrocytoma from astrocytoma is difficult, relying on morphological characteristics due to the lack of reliable immunohistochemical stains. Oligodendrocytes, the presumed cell of origin of oligodendrogliomas, highly express the genes encoding myelin basic protein (MBP) and proteolipid protein (PLP). We analyzed the expression of t...
Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and t...
Glioma is the most common form of primary brain tumor. Although surgical resection of the tumor may be achieved, recurrence is almost inevitable because of the propensity of gliomas for infiltrative growth far into functionally intact brain tissue. Gliomas are classified into four clinical grades, with glioblastoma multiforme (GBM) being the most aggressive type (World Health Organization [WHO]...
Five cases of anaplastic oligodendrogliomas containing numerous GFAP-positive cells have been analysed by electron microscopy to establish the fine structural characteristics of neoplastic cells. Ultrastructurally, all tumours have revealed monotonous appearance typical of oligodendrogliomas, however some structural variability, particularly with reference to astrocytic differentiation, has bee...
Abstract Introduction In consonance with current the World Health Organization (WHO) classification of central nervous system (CNS) tumors (2016), histological diagnosis gliomas should be reinforced by molecular information. This study was performed to determine frequency isocitrate dehydrogenase 1 (IDH1), α thalassemia/intellectual disability syndrome X-linked (ATRX), p53, and BRAF V600E mutat...
Refractile eosinophilic granular cells, when present in abundance in a glioma, may trigger a diagnosis of the relatively familiar and inherently malignant 'granular cell astrocytoma'. The following two cases remind us that refractile eosinophilic granular cells are not unique to granular cell astrocytoma but can also dominate the histology of oligodendroglioma confirmed by 1p19q loss, and the i...
The interest in oligodendrogliomas has increased since it became evident that a subset of these tumors respond to chemotherapy or radiation. This interest was augmented when the combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 was identified as a powerful prediction factor for response. Lack of stringent morphological criteria allow high-interobserver variation w...
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