HAC estimators are known to produce test statistics that reject too frequently in finite samples. One neglected reason comes from using the OLS residuals when constructing the HAC estimator. If the regression matrix contains high leverage points, such as from outliers, then the OLS residuals will be negatively biased. This reduces the variance of the OLS residuals and the HAC estimator takes th...

Developing oligodendrocytes (OLs) are highly vulnerable to glutamate excitotoxicity. Although OL excitotoxicity is mainly mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (AMPARs) and is Ca2+-dependent, the molecular basis for AMPAR-mediated Ca2+ influx in OLs remains largely unclear. Ca2+ permeability of AMPARs is inversely correlated with the abundance of the...

This paper compares ordinary least squares (OLS), weighted least squares (WLS), and adaptive least squares (ALS) by means of a Monte Carlo study and an application to two empirical data sets. Overall, ALS emerges as the winner: It achieves most or even all of the efficiency gains of WLS over OLS when WLS outperforms OLS, but it only has very limited downside risk compared to OLS when OLS outper...

M yelin is the membranous structure that wraps around axonal segments and supports the fast saltatory conduction of action potentials along axons (1, 2). Disorders that disrupt myelin during development or in adulthood, such as multiple sclerosis, lead to severe pathologies, illustrating myelin’s crucial role in normal neural functioning. In the central nervous system, oligodendrocytes (OLs) ar...

An efficient palladium-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols has been developed via capture of the active tautomers. A wide variety of 2,5-disubstituted and 2,4,5-trisubstituted pyrazolidinones have been synthesized with up to 96% and 95% ee, respectively. The hydrogenation pathway includes Brønsted acid promoted tautomerization of pyrazol-5-ols and Pd-catalyz...

Spare representation of signals has received significant attention in recent years. Based on these developments, a sparse representation-based classification (SRC) has been proposed for a variety of classification and related tasks, including face recognition. Recently, a class dependent variant of SRC was proposed to overcome the limitations of SRC for remote sensing image classification. Trad...

Oral leukoplakia (OL) is the most common potentially malignant lesion of the oral cavity. Immunohistochemical analysis of p53 and Ki67 proteins is a simple and inexpensive method widely used in non-dysplastic OLs to reveal lesions predicted to develop oral cancer. The present longitudinal study evaluated the predictive role of p53 and Ki67 proteins alone or in combination in a group of OLs with...

Taking advantage of both the scaling property of wavelets and the high learning ability of neural networks, wavelet networks have recently emerged as a powerful tool in many applications in the field of signal processing such as data compression, function approximation as well as image recognition and classification. A novel wavelet network-based method for image classification is presented in ...