نتایج جستجو برای: oltipraz

تعداد نتایج: 196  

Journal: :Cancer research 2000
V P Kelly E M Ellis M M Manson S A Chanas G J Moffat R McLeod D J Judah G E Neal J D Hayes

Structurally diverse compounds can confer resistance to aflatoxin B1 (AFB1) hepatocarcinogenesis in the rat. Treatment with either phytochemicals [benzyl isothiocyanate, coumarin (CMRN), or indole-3-carbinol] or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl maleate, ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to i...

2013
Safwan Ashour Roula Bayram

Aim: To develop and validate a sensitive method for the determination of rapeprazole (RPZ) and omeprazole (OPZ) in bulk and formulations based on nucleophilic substitution reaction of RPZ and OPZ with sodium 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium. Study Design: All variables were studied to optimize the reaction conditions and the reaction mechanism was postulated. Place an...

Journal: :Bioorganic & medicinal chemistry 2010
Sanjib Bhattacharyya Haiying Zhou Derrick R Seiner Kent S Gates

Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex. In addition to Keap1-Nrf2, dithiolethiones have the potential to modify a variety of cysteine-containing proteins in the cell. Such 'off target' reactions could contribute to either side effects or cancer-preventive efficacy. Evidence is pres...

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