Bax is a crucial mediator of the mitochondrial pathway for apoptosis, and loss of this proapoptotic Bcl-2 family protein contributes to drug resistance in human cancers. We report here that the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin (THG) induces apoptosis of human colon cancer HCT116 cells through a Bax-dependent signaling pathway controlling the cytosolic release of mitoch...

The Ozone Monitoring Instrument (OMI) is an imaging UV-VIS solar backscatter spectrometer and is designed and used primarily to retrieve trace gases like O3 and NO2 from the measured Earth reflectance spectrum in the UV-visible (270–500 nm). However, also aerosols are an important science target of OMI. The multi-wavelength algorithm is used to retrieve aerosol parameters from OMI spectral refl...

[1] The Dutch-Finnish Ozone Monitoring Instrument (OMI) launched on the NASA Aura satellite in July 2004 offers unprecedented spatial resolution, coupled with contiguous daily global coverage, for space-based UV measurements of sulfur dioxide (SO2). We present a first validation of the OMI SO2 data with in situ aircraft measurements in NE China in April 2005. The study demonstrates that OMI can...

[1] In this paper we present the validation results of the operational vertical ozone profiles retrieved from the nadir observations by the Ozone Monitoring Instrument (OMI) aboard the NASA Earth Observing System (EOS) Aura platform. The operational ozone profile retrieval algorithm was developed at the Royal Netherlands Meteorological Institute and the OMI mission data has been processed and m...

OBJECTIVE To determine the success rate and the factors related to the success rate of orthodontic miniscrew implants (OMI) placed at the attached gingiva of the posterior buccal region. MATERIALS AND METHODS Four hundred eighty OMI placed in 209 orthodontic patients were examined retroactively. The sample was divided into young patients (range 10-18 years, N = 108) and adult patients (range ...

The discrimination of cloudy from cloud-free pixels is required in almost any estimate of a parameter retrieved from satellite data in the ultraviolet (UV), visible (VIS) or infrared (IR) parts of the electromagnetic spectrum. In this paper we report on the development of a neural network (NN) algorithm to estimate cloud fractions using radiances measured at the top of the atmosphere with the N...

The Pearl River delta (PRD) is a densely populated hub of industrial activity located in southern China. OMI (Ozone Monitoring Instrument) satellite observations reveal a large hotspot of glyoxal (CHOCHO) over the PRD that is almost twice as large as any other in Asia. Formaldehyde (HCHO) and NO2 observed by OMI are also high in the PRD but no more than in other urban/industrial areas of China....

AIM To evaluate the long-term effects of peripheral blood stem cell therapy in myocardial infarction (MI) patients. METHODS AND RESULTS A total of 163 patients with MI who were successfully revascularized with drug-eluting stents were enrolled and randomly assigned to four groups: acute MI (AMI) cell infusion, AMI control, old MI (OMI) cell infusion, and OMI control. We compared 5 years' clin...

OBJECTIVES Three-dimensional organoids derived from primary pancreatic ductal adenocarcinomas are an attractive platform for testing potential anticancer drugs on patient-specific tissue. Optical metabolic imaging (OMI) is a novel tool used to assess drug-induced changes in cellular metabolism, and its quantitative end point, the OMI index, is evaluated as a biomarker of drug response in pancre...

Oncogenic Ras induces cell transformation and promotes an invasive phenotype. The tumor suppressor p53 has a suppressive role in Ras-driven invasion. However, its mechanism remains poorly understood. Here we show that p53 induces activation of the mitochondrial protease high-temperature requirement A2 (HtrA2; also known as Omi) and prevents Ras-driven invasion by modulating the actin cytoskelet...