a simple and efficient one-pot, three-component strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. the reaction was carried out in the presence of catalytic amount of phosphotungstic acid (h3[p(w3o10)4]) as an environmentally friendly catalyst.

1,3-dibromo-5,5-dimethylhydantoin (dbh) and benzyltriphenylphosphoniumtribromide (btptb) were used as efficient catalysts for the promotion of the synthesis of 1,8-dioxo-octahydroxanthene derivatives (doxos) via a one-pot three component condensation of aldehydes and cyclic 1,3-dicarbonyl compounds in the absence of solvent.

sulfuric acid {[3-(3-silicapropyl)sulfanyl]propyl}ester (saspspe) is employed as a recyclable catalyst for the synthesis of α-amino nitriles. these syntheses were performed via a one-pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide under mild reaction conditions at room temperature. the catalyst could be recycled and reused several times without any loss of effi...

an efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. the procedure employs a three-component condensation reaction in one-pot using 2h-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence of catalytic amount of l-prolinein aqueous media.

A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed...

maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synthesis of 3,4,5-substituted furan-2(5h)one derivatives via a one-pot three-component reaction of arylamines, aromatic aldehydes and dialkyl acetylenedicarboxylates in water. this method has notable advantages in terms of simple workup, no need for column chromatography, short reaction time and high y...