BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between BRCA1 and BACH1, lead to defects in DNA repair, and result in breast and ovarian cancer. BACH1 is necessary for efficient double-strand break repair in a manner that depends on its association with...

Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. Inactivating mutations in RECQL2 lead to Werner syndrome, a rare autosomal disease associated with premature aging and an increased susceptibility to multiple cancer types. We analyzed the association of two coding single-nucleotide polymorphisms in WRN, Cys1367Arg (rs1346044),...

The aims of our study were: (1) to detect disease-associated BRCA1 mutations in a series of Portuguese patients with breast and/or ovarian cancer; (2) to evaluate the expression of molecular markers of biological behaviour, namely ER, proliferative index, c-erb-B2, p53, sialyl-Tn and angiogenic index in a series of hereditary breast cancer (HBC) in relation to sporadic cases. We selected 65 pat...

introduction: the adaptive neuro-fuzzy inference system (anfis) is a soft computing model based on neural network precision and fuzzy decision-making advantages, which can highly facilitate diagnostic modeling. in this study we used this model in breast cancer detection. methodology: a set of 1,508 records on cancerous and non-cancerous participant’s risk factors was used.  first, the risk fact...

conclusions expression of armc3 in tumor samples and normal adjacent tissue is very important. the expression of this gene in tumor-adjacent tissue may be associated with the stage of cancer; it may be that these tissues are affected by epigenetic and oncogenic changes of breast cancer. accordingly, aberrant expression of armc3 in tumor samples may be an attractive candidate for use as a tumor ...

BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred population, the prevalence of BRCA1 and BRCA2 mutations in patients with breast cancer who were unselected for a family history of this disease has not been determined. METHODS Mutations in the BRCA1 a...

background: idiopathic granulomatous mastitis (igm) is a rare benign breast disease, which can mimic breast cancer. as the managements of igm and breast cancer are entirely different and the initial clinical manifestations are similar in several cases, it is very important to differentiate them. case presentation: we reported a 48-year-old female patient with igm and breast cancer. she was refe...

background: potential association of leptin (lep) gene polymorphisms has been suggested in the processes leading to breast cancer initiation and progression. we investigated whether genetic variations in the lep -2548g/a gene are associated with risk of breast cancer. methods: this case-control study consisted of 100 breast cancer cases and 100 control subjects without breast cancer that matche...

mri of the breast has evolved as a non-invasive imaging modality and is ideally suited for several indications e.g. pre-operative staging and screening in women at increased risk for breast cancer. the widespread use opens also the discussion on over-diagnosis if only 20 - 30 out of 100 mri - guided breast biopsies lead to the diagnosis of breast cancer. thus mri based strategies are needed to ...

B reast cancer is the third most common form of cancer worldwide, after lung and stomach cancer, and is the most common cause of cancer death in women. The age-adjusted incidence rates of breast cancer are 176% higher in developed than developing countries. In Singapore, breast cancer is the most common cancer in women and the incidence rate in 1993–1997 was 2.3 times higher than in 1968–1972, ...