Background Berotralstat (BCX7353) is an oral, once-daily inhibitor of plasma kallikrein recently approved for prevention angioedema attacks in adults and adolescents with hereditary (HAE). The objective this report to summarize results from interim analysis ongoing long-term safety study berotralstat patients HAE. Methods APeX-S ongoing, phase 2, open-label conducted 22 countries (ClinicalTrial...

The literature is almost devoid of scientific studies of diagnosis of pulpal pathology in primary and permanent teeth with open apices. Most reports are empirical or retrospective studies without adequate prior knowledge of preexisting conditions or histologic findings leading to the necessity of pulpal procedures. Appropriate diagnostic tests and their effectiveness are documented for both gro...

The study was performed in 20 children with partial anterior open bite and in 20 children of a control group. Stereognosis was evaluated on the basis of correct recognition responses to silicone pieces of the different shapes. Pieces were put on the dorsal surface of the tongue close to its apex. It was evident that the stereognostic ability was impaired in children with anterior open bite. Thi...

Injury to an immature permanent tooth may result in cessation of dentin deposition and root maturation leaving an open root apex and thin dentinal walls that are prone to fracture. Endodontic treatment is often complicated and protracted with an uncertain prognosis frequently resulting in pre-mature tooth loss. There are several advantages of promoting apexogenesis in immature teeth with open a...

The new airborne imaging spectrometer APEX will be available in 2006. It observes the visible and short-wave infrared spectral ranges. With its unique combination of spectral and spatial resolution, atmospheric molecular spectroscopy is feasible with unprecedented spatial resolution and coverage. Sensitivity calculations show, that abundances of CO2 and CH4 and pollution events of NO2 and O3 in...

In 1943, Hadwiger made the conjecture that every loopless graph not contractible to the complete graph on t+1 vertices is t-colourable. When t ≤ 3 this is easy, and when t = 4, Wagner’s theorem of 1937 shows the conjecture to be equivalent to the four-colour conjecture (the 4CC). However, when t ≥ 5 it has remained open. Here we show that when t = 5 it is also equivalent to the 4CC. More precis...