A series of compounds related to ameltolide were studied for anticonvulsant potential in the subcutaneous pentylenetetrazol (sc Ptz) test in mice. These compounds were synthesized and characterized by TLC followed by IR and H1NMR. In vivo screening data acquired indicate that most of analogs have the ability to protect against PTZ-induced seizure. Phenytoin (PHT) was employed as the reference p...

Open channel junction is one of the most common hydraulic structures that are used in various practical situations such as sewer, drainage, and flood control systems. Knowing the fluid flow behavior, is one of the most important topics in designing the efficient open channel junctions. The complexity and deviation of flow in the junction’s zone disrupts the proper functioning of the flowmeter d...

On the basis of the state–space method (SSM), a novel linear mathematical model of the unsteady flow for the tailrace system with an open channel is proposed. This novel model is an elastic linearized model of water hammer. The validity of the model has been verified by several examples of numerical simulation, which are based on a finite difference technique. Then, the complete mathematical mo...

Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, which involve the voltage-dependent release of an open channel blocker. In contrast, IEM mutations, ...

extensive researches on wireless sensor networks (wsns) have been performed and many techniques have been developed for the data link (mac) layer. most of them assume single-channel mac protocols. in the usual dense deployment of the sensor networks, single-channel mac protocols may be deficient because of radio collisions and limited bandwidth. hence, using multiple channels can significantly ...

the purpose of this paper is to present a 2d depth-averaged model for simulating and examining unsteady flow patterns in open channel bends. in particular, this paper proposes a 2d depth-averaged model that takes into account the influence of the secondary flow phenomenon through calculation of the dispersion stresses. the dispersion terms which arose from the integration of the product of the ...

cohesive sediment transport remains a complicated subject that hydraulic engineers are frequently faced with in water-related engineering problems. this is primarily affected by the macroscopic aspects of water-sediment system characteristics. in this paper a 1-d mathematical model was developed to be employed in predicting the cohesive sediment transport under simultaneous conditions of erosio...