Patch pipettes were used to record the current arising from small populations of sodium channels in voltage-clamped cut-open squid axons. The current fluctuations associated with the time-variant sodium conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single sodium channel. The results presented support the notion that t...

here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles ...

BACKGROUND Clinical trials have not yet compared the efficacy of capsaicin 8% patch with current standard therapy in peripheral neuropathic pain (PNP). OBJECTIVES Head-to-head efficacy and safety trial comparing the capsaicin patch with pregabalin in PNP. METHODS Open-label, randomized, multicentre, non-inferiority trial. Patients with PNP, aged 18-80 years, were randomly assigned to either...

Na+ currents were measured during 0.4-s depolarizing pulses using the cell-attached variation of the patch-clamp technique. Patches on Cs-dialyzed segments of sartorius muscle of Rana pipiens contained an estimated 25-500 Na+ channels. Three distinct types of current were observed after the pulse onset: a large initial surge of inward current that decayed within 10 ms (early currents), a steady...

The plug-and-patch technique is frequently used for the open repair of inguinal hernias; however, serious complications may arise on rare occasions. We present the case of a 69-year-old patient who presented with a colocutaneous fistula with the sigmoid colon 9 years after the repair of a left sliding inguinal hernia with the plug-and-patch technique. The patient underwent sigmoidectomy and exc...

We report a case of an 86 year old female that presented with a refractory cerebrospinal fluid fistula after L2-L5 posterior decompression. An epidural blood patch was performed on post-operative day 21, and the leakage of cerebrospinal fluid ceased soon after the procedure, thus avoiding the need for open closure. One year after surgery, the patient showed improvement in intermittent claudicat...

Surgical management of massive rotator cuff tears remains challenging, with failure rates ranging from 20% to 90%. Multiple different arthroscopic and open techniques have been described, but there is no current gold standard. Failure after rotator cuff repair is typically multifactorial; however, failure of tendon-footprint healing is often implicated. Patch augmentation has been described as ...

A 59-year-old man, with no history of atopy or allergy, had long been treated for open-angle glaucoma with eyedrops containing the β-blocker betaxolol (Betoptic®) when he developed acute eyelid dermatitis, associated with conjunctival hyperaemia (Fig. 1). His condition rapidly improved after withdrawing betaxolol and using topical corticosteroids. Patch testing with the European baseline series...

The objective of this Electronic Supplement is to present in a concise manner the kinematic approach of limit analysis for fluid saturated media as proposed in details by Leroy and Pons (2012). The limit analysis approach [Chandrasekharaiah and Debnath, 1994; Salençon, 2002] is based on the principle of virtual powers and the theorem of maximum rock strength [Maillot and Leroy, 2006]. The metho...

Does secrecy improve security or impede securing software updates? The automotive industry has traditionally relied upon proprietary strategies developed behind closed doors. However, experience in the software security community suggests that open development processes can find flaws before they can be exploited. We introduce Uptane, a secure system for updating software on automobiles that fo...