BACKGROUND/AIM The effect of drugs leaves permanent consequences on the brain, organic in type, followed by numerous manifestations, and it significantly affects the development of mental dysfunctions. The clinicians are often given a task to estimate a patient's personality during treatment or during experts estimate of a drug addict. The aim of this research was to determine the differences, ...

background: although opioids suppressive effects on immune system function have been reported, this study demonstrates inflammatory reactions, such as production of pro-inflammatory cytokines and suppression of anti-inflammatory cytokines, are the main causes at organ’s allotransplantation rejection in chronic morphine-treated recipients. methods: 28 rats were categorized in 4groups through int...

INTRODUCTION Some research results point to significant benefit in the use of methadone substitution treatment in reduction of criminogenic activities in opiate addicts, as in positive affect on their somatic and mental state. OBJECTIVE The objective of the study was to indicate factors which lead to criminogenic activities in addicts with judicial problems before entering substitute, methado...

BACKGROUND Given the increasing number of lead poisoning in opioids users and since no study has been conducted so far to review lead poisoning in methamphetamine (crystal) users, this study aimed to investigate blood lead level in methamphetamine addicts. METHODS This study was conducted on 20 patients with methamphetamine poisoning and their blood lead level was measured. The subjects were ...

BACKGROUND Buprenorphine, a synthetic molecule derived from thebaine, has been commercialized in France since 1987 as a substitute treatment for pharmacodependence on opiates. Hepatotoxicity is poorly documented, since only few cases of hepatic injury have been reported. METHODS We report seven cases of acute cytolytic hepatitis due to buprenorphine. All patients were former drug addicts by t...

A form for recording acute toxicological cases has been preliminarily applied to a sample of 436 subjects admitted during 1978 into the hospitals of two districts of the Venetian Region. One was predominately manufacture and industry, and the other a mountain-agricultural area. The latter had medical facilities less uniformly distributed. Through epidemiological analysis, the acute poisoning ca...

The popular view of the major function of the opiates is that they produce analgesia. Much evidence has been accumulated that the endogenous opiates play an integral role in the central regulation of appetite. We postulate that the major effect of the endogenous opiates is to induce the feeding drive with their analgesic properties representing an epiphenomenon. Am J Cli,, Nuir 1982;35:757-76l.