نتایج جستجو برای: optical isomers
تعداد نتایج: 275969 فیلتر نتایج به سال:
Although it is generally agreed that general anesthetics ultimately act on neuronal ion channels, there is considerable controversy over whether this occurs by direct binding to protein or secondarily by nonspecific perturbation of lipids. Very pure optical isomers of the inhalational general anesthetic isoflurane exhibited clear stereoselectivity in their effects on particularly sensitive ion ...
Optically active isomers of N-methy1-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine3-carboxamides(( + )-2 and(-)-2) have been synthesized and tested for positive inotropic activity. The racemic thiocarboxamide((•})-3) was resolved into the enantiomers(( + )-3 and(•E)-3) via the Land D-N-(2-naphthylsulfonyl)prolyl derivatives ((+ )-4 and (-)-4). Conversion of the thiocarboxamides (( + )-...
Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched. Single crystals of both compounds were obtained for X-ray analysis, and the absolute configurations (ACs) have been further confirmed by electronic ci...
■ ■ Reliable and reproducible measurement of the enantiomeric and/or diastereomeric ratios. IN T RO DU C T IO N The development of analytical methods for the separation of chiral compounds is important in many areas of research, as it is well known that different enantiomers are selectively biologically active. Biochemical reactions can be diastereo or enantioselective. While one isomer may del...
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