We report here the use of the theory of independent component analysis (ICA), a recently developed technique of data representation, for development of an algorithm for diagnosis of early stage cancer of human oral cavity. The algorithm has been developed using spectral data acquired in a clinical in-vivo laser-induced fluorescence (LIF) spectroscopic study conducted on normal volunteers and pa...

The article presents an analytical review of current data on the effectiveness use obturator prostheses in patients with oral cancer after treatment. Literature search was performed Ovid MEDLINE, Embase, Web Science, PubMed, Scopus, Yandex period 2012 – 2022. terms were head and neck cancer, cavity orthopedic dental rehabilitation, prosthetics, prosthesis. success rehabilitation prosthesis depe...

Oral cancer refers to all malignancies that arise in the oral cavity, lips and pharynx, with 90% of all oral cancers being oral squamous cell carcinoma. Despite the recent treatment advances, oral cancer is reported as having one of the highest mortality ratios amongst other malignancies and this can much be attributed to the late diagnosis of the disease. Saliva has long been tested as a valua...

Oral cancer is the sixth common tumour worldwide [1]. Oral cancer is the fourth leading cause of cancer death for males [2]. Oral squamous cell carcinoma (OSCC) is the most common neoplasia and is found frequently in oral cavity in the cheek, gingiva and tongue [3]. Although cigarette and alcohol are considered as two major etiological factors of oral carcinogenesis [4], occurrence of oral canc...

Let-7 and Lin28 establish a double-negative feedback loop to affect several biological processes, such as differentiation of stem cell, invasion and metastasis, and tumorigenesis. In this study, we systematically investigated the associations between 6 potentially functional SNPs of let7 and Lin28 genes and the risk of oral cavity cancer with a case-control study including 384 oral cavity cance...

OBJECTIVE The aim of this study was to evaluate the magnitude of oxidative stress and levels of nitric oxide in patients with oral cavity cancer by analyzing the levels of lipid peroxidation products, antioxidants and nitric oxide products. METHODS This prospective study was conducted on 15 patients with biopsy proven squamous cell cancer of the oral cavity with clinical stage III/IV and an e...

The goal of this research was to determine the existence of the significant time differences in the identification of the recurrences and neck metastases in the patients surgically treated for the oral cavity cancer by comparing three postoperative follow up methods. The study included 286 patients surgically treated for oral and pharyngeal cancer in period from 1991 to 2007 at three different ...

abstract background and aims. reliable immunohistochemical assays to evaluate the definitive role of mast cells and angiogenesis in the pathogenesis of oral reactive lesions are generally not available. the purpose of the present study was to compare mast cell count (mcc) and microvessel density (mvd) between oral reactive lesions and evaluation of the correlation between mcc and mvd in these l...

to evaluate the effect of adding neoadjuvant chemotherapy to surgery and radiation therapy for locally advanced resectable oral cavity squamous cell carcinoma, 24 patients with t3 or t4a oral cavity squamous cell carcinoma were randomly assigned to surgery alone or docetaxel, cisplatin, and 5-fu (tpf) induction chemotherapy followed by surgery. all patients were planned to receive chemoradiothe...

Introduction: Oral squamous cell carcinoma (OSCC) is the world's sixth malignant disease with multifactorial causes. Nitrosamine compounds can be found in saliva and used as a biomarker for early detection of oral cancer. Carcinogenic nitrosamines derived from tobacco use contact normal cavity cells. It affects process controlling growth by interfering DNA translation. This study aims to determ...