Dr. Sherin A Khalam1, Dr. Surej Kumar LK2, Dr. Rakesh Koshy Zacariah3, Dr. Nikhil Mathew Kurien3 and Dr. Prabhat Raj4 1Associate Professor, Department of Oral & Maxillofacial Surgery, PMS College Of Dental Science & Research, Trivandrum, India 2Professor & Head, Department of Oral & Maxillofacial Surgery, PMS College Of Dental Science & Research, Trivandrum, India 3Professor, Department of Oral...

Medical images form an essential source of information for various important tasks such as diagnosis of diseases, surgical planning, medical reference, research and training. Oral submucous fibrosis [OSMF] is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues. Support Vector Machine [SVM] is a statistic machine lear...

Areca quid chewing related oral mucosal lesions are potential hazard to a large population worldwide. Commercially freeze dried products such as pan masala, Guthka and mawa have high concentration of areca nut per chew and appear to cause OSMF more rapidly than by self prepared conventional betel quid that contain smaller amounts of areca nut. These chemical appear to interfere with the molecul...

Dear Editor, A b o u t 5 m i l l i o n p e o p l e i n I n d i a h ave o r a l submucous fibrosis and recent data suggest a male predominance. Age group between second and third decade is commonly involved. Risk of malignant transformation ranges from 7% to 30%. Restricted mouth opening in oral submucous fibrosis makes examination and early diagnosis of cancer difficult. Medical management is t...

Oral submucous fibrosis (OSMF) is a collagen disorder commonly seen in the Indian subcontinent ,it is a complex precancerous condition. It was initially found mainly in India but it is now often seen in the Asian populations belonging to United Kingdom, USA, and other developed countries, and is therefore a serious concert for global health, causative agent of osmf is considered to be areca-nut...

Several studies have demonstrated an independent association of deleterious oral habits such as smoking, betel quid chewing, and chewing tobacco with the occurrence of oral cancer. The potentially malignant conditions such as oral submucous fibrosis (OSF), leukoplakia, erythroplakia associated with smoking, and smokeless tobacco, have a greater prevalence in our country. OSF has high cancer tur...

BACKGROUND Oral submucous fibrosis (OSF), a potentially malignant oral lesion, is a form of pathological fibrosis affecting the oral mucosa. It results from an imbalance in equilibrium of the normal process of synthesis and degradation of extra cellular matrix. Matrix metalloproteinases and its inhibitors play important role in remodeling of the extra cellular matrix which are important in prog...

Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs)which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. Thisstudy evaluated the quantitative expression of EGFR in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with th...