BACKGROUND OA is a complex disease caused by environmental and genetic risk factors. The purpose of this study is to identify candidate copy number variations (CNVs) associated with OA. METHODS We performed a genome-wide association study of CNV to identify potential loci that confer susceptibility to or protection from OA. CNV genotyping was conducted using NimbleGen HD2 3 × 720K comparative...

Orthogonal Array Testing is one of the most important techniques that produce test cases which are much lesser in number than black box testing, but are more relevant. In spite of its importance, the technique has not been explored as much as other techniques. The present work, therefore, explores the literature to find the gaps in the literature and hence propose a new technique based on Genet...

This paper describes a state space discretization scheme based on statistical experimental designs generated from orthogonal arrays of strength three with index unity. Chen et al. (1999) employed this eecient discretization scheme in a numerical solution method for high-dimensional continuous-state stochastic dynamic programming (SDP). These OAs are instrumental in reducing the dimensionality o...

CNC machine tool is widely used by manufacturing engineers and production personnel to quickly and effectively set up manufacturing processes for new products. This study discusses an investigation into the use of Taguchi Parameter Design methodology for study of CNC turning operation for surface roughness as a response variable. The Taguchi parameter design method is an efficient experimental ...

It is proved that the collection of blocks of an affine 1-design that yields a linear orthogonal array is a union of parallel classes of hyperplanes in a finite affine space. In particular, for every prime power q and every m ≥ 2 there exists a unique (up to equivalence) complete linear orthogonal array of strength two associated with the classical design of points and hyperplanes in AG(m, q).

this study focused on the optimization of al—mg to cuzn34 friction stir lap welding (fslw) process for optimal combination of rotational and traverse speeds in order to yield favorable fracture load using grey relational analysis (gra). first, the degree of freedom was calculated for the system. then, the experiments based on the target values and number of considered levels, corresponding orth...

We study constant coefficient four term recurrences for polynomials, in analogy to the three-term recurrences that are associated with orthogonal polynomials. We show that for a family of polynomials obeying such a four-term recurrence, the coefficient array is an ordinary Riordan array of a special type, and vice versa. In certain cases, it is possible to transform these polynomials into relat...

In this work we solve the problem of architecting a conceptual, near-term, cost-effective system of systems (SoS) to respond to small boats used by terrorists to attack maritime commerce traffic and critical shore infrastructures in the United States, by formulating the architecting problem as an assignment problem which is then solved using the orthogonal array experiment. Also known as the Ta...

In recent years, breakthroughs in electronics technology have resulted upgrades the physical properties of metal oxide semiconductor field effect transistor (MOSFET) toward smaller sizes and improvements both quality performance. Hence, growth (GFET) is being promoted as one worthy contenders due to its superior material characteristics. A 14 nm horizontal double-gate bilayer graphene FET with ...

in this study, amine functionalized kit-6 silica mesoporous magnetite nanocomposite (nh2-mmnc) was synthesized by chemical methods and used as an efficient and recoverable adsorbent for removal of ponceau 4r, as a toxic dye, from aqueous solutions. the synthesized nanocomposites were characterized by xrd, ft-ir, bet and sem instruments. the effect of various experimental parameters on the dye r...