BACKGROUND Immunotherapy plays a key role in the treatment of metastatic melanoma. Patients with autoimmune conditions and/or on immunosuppressive therapy due to orthotropic transplants, however, are systematically excluded from clinical trials. Talimogene laherparepvec (T-VEC) is the first oncolytic virus to be approved by the FDA for cancer therapy. To our knowledge, this is the first report ...

The generalized integral transform technique (GITT) is employed to obtain an exact solution for the bending problem of fully clamped orthotropic rectangular plates. The use of the GITT approach in the analysis of the transverse deflection equation leads to a coupled system of fourth order differential equations in the dimensionless longitudinal spatial variable. The resulting transformed ODE sy...

Recently, graphene sheets have shown significant potential for environmental engineering applications such as wastewater treatment. In the present work, the posbuckling response of orthotropic single-layered graphene sheet (SLGS) is investigated in a closedform analytical manner using the nonlocal theory of Eringen. Two opposite edges of the plate are subjected to normal stresses. The nonlocali...

The in-plane behaviour of tetrachiral lattices should be characterized by bi-dimensional orthotropic material owing to the existence of two orthogonal axes of rotational symmetry. Moreover, the constitutive model must also represent the chirality inherent in the lattices. To this end, a bi-dimensional orthotropic chiral micropolar model is developed based on the theory of irreducible orthogonal...

Objective: The objective is to obtain the stresses due to strip loading in orthotropic plate lying over an irregular isotropic elastic medium. Methods: Anti-plane strain problem with perfect bonding boundary conditions following by Fourier Transformation on the equilibrium equation are used to obtain the solution. The deformation field due to shear line load at any point of the medium consistin...

In this paper, plane thermo-elastic solutions are presented for the problem of a crack in two bonded homogeneous orthotropic media with a graded interfacial zone. The graded interfacial zone is treated as a nonhomogeneous interlayer having spatially varying thermo-elastic moduli between dissimilar, homogeneous orthotropic half-planes, which is assumed to vary exponentially in the direction perp...

An integral transform technique is used to solve the elastodynamic problem of a crack of fixed length propagating at a constant speed at the interface of two bonded dissimilar orthotropic layers of equal thickness. Two cases of practical importance are investigated. Firstly, the lateral boundaries of the layers are clamped and displaced in equal and opposite directions to produce antiplane shea...

landmark based geometric morphometrics and comparison of meristic characters was used to understand potential differences between populations of waspi in mashkil and mokran basins. 97 specimens of waspies were caught (64 from mashkil river and 33 from sarbaz river). 14 landmarks were digitized on pictures taken from left side of specimens and meristic characters were counted. data were analyzed...

reelin is an extracellular matrix neuroprotein which plays important roles during development and maturation of cerebellum. in the postnatal cerebellum, reelin is synthesized by cerebellar granule cells and secreted to extracellular matrix. this secreted protein modulates adult synaptic function, neurotransmitter release and regulates plasticity. exercise has beneficial effects on central nervo...