Background: Follicular pool is reduced after transplantation of vitrified ovary. Therefore, methods should be improved to accelerate ovarian function revival and maintain follicular reserve. In this study hyaluronic acid hydrogel as a scaffold was used to improve restoration of ovarian oestrous cycle. Materials and Methods: 79 mature (~8 weeks) rats having normal estrous cycles were divided int...

Some authors doubt the occurrence of a primary hypernephroma of the ovary and consider ovarian tumors resembling the classic renal hypernephroma as having arisen from lutein cells. Others, emphasizing the sharp differences between the development and arrangement of lutein cells and those of the socalled ovarian hypernephroma, accept the latter as a tumor entity, without reserve. At the present ...

In the current issueofHumanReproduction vanDorp et al. (2013) provide uswith seminal evidence about a serummarker that purportedly informs us about current and future ovarian function. Current dogma attributes to this marker the ability to determine the number of primordial follicles remaining in the ovary. The findings in this publication force us to reconsider this long-held view. I congratul...

Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessiv...

The primordial follicle assembly, activation and the subsequent development are critical processes for female reproduction. A limited number of primordial follicles are activated to enter the growing follicle pool each wave, and the primordial follicle pool progressively diminishes over a woman's life-time. The number of remaining primordial follicles represents the ovarian reserve. Identificat...

Although androgen excess is considered detrimental to women's health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout mouse models have been used to show that androgen actions through ARs are actually necessary for normal ovarian function and female fertility. Here we describe two AR-mediated pathways in granulosa cells that regulate ovarian follicular d...

Background and Objective: Contraception is widely used throughout the world, with 62% of reproductive-aged women. This trial was established to assess effect prolonged use hormonal contraception (HC) on ovarian reserve. Methods: retrospective randomized controlled performed 150 healthy females aged (20-35) years normal menstrual history had at least one offspring after spontaneous pregnancy. Pa...

With great interest we read the article by Zhai et al. [1] in the June 2012 issue of the Journal of Pediatric Surgery regarding gonadal function after childhood ovarian surgery. The authors show that unilateral oophorectomy compared to ovarian salvage does not appear to impair late gonadal function after childhood ovarian surgery. Interestingly, they observed that unilateral oophorectomy appear...

OBJECTIVE Due to a background of high prevalence of type 2 diabetes and the increasing rate of obesity occurring in relatively young urban children, we felt the need to look for type 2 diabetes in children. RESEARCH DESIGN AND METHODS A study of cases of type 2 diabetes with age at diagnosis of </=15 years seen at a diabetes speciality center in Chennai, India, is reported. A total of 18 chil...