introduction: this study was designed to evaluate the effects of treatment with flaxseed oil (fso) on renal ischemia-reperfusion (rir) injuries in rats. materials and methods: in this study, 32 wistar rats were randomly studied in four groups: co+ns (control group with normal saline administration), sh+ns (sham group with normal saline administration), rir+ns and rir+fso. fso (0.2 ml) was admin...

background: recent results have provided increasing evidence to support involvement of membrane damage in the mechanism of ionizing radiation induced killing of mammalian cells. these findings have stimulated renewed interest in evaluating the damage to membrane as a primary initiator in radiation-induced cell killing especially in apoptotic death. the present study was aimed to gain deeper ins...

background: glucocorticoids have several benefits in large animal medicine but apart from their benefits, there are several disadvantages attributed to the use of these drugs. among the disadvantages, disturbance in protein metabolism is one of the side effects of glucocorticoids which has been investigated in human and laboratory animals. objectives: there are no information regarding the effe...

toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. the present study was performed to investigate the toxic effects of monensin in goats. seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. monensin toxicity was evaluated by clinical signs, serum bioch...

grape seed proanthocyanidin (gsp) bears a very powerful antioxidant effects. studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. the present study was designed to assess the effect of gsp on the heart of diabetic rats. forty rats were divided into four groups of 10 animals each: group i: control, group ii: control group were giv...

camel milk has an importance in the treatment of diabetes. it has been shown that the patients who drink camel milk daily, their need to insulin decrease. therefore, this study aimed to investigate the effect of camel milk in comparison with insulin treatment in experimentally-induced diabetes. this study was carried out on forty male new zealand rabbits, divided into four groups with ten rabbi...

objective: it has been shown that deferasirox can reduce blood and tissues lead content in animal models. in this study the effect of deferasirox alone or combined with glycine as an antioxidant was evaluated in chronic cadmium toxicosis in rat. methods: male wistar albino rats were exposed to 200 ppm cadmium in the drinking water for 3 weeks and treated thereafter with deferasirox (140 mg/kg),...

conclusions in the literature, it was observed that short-term msg exposure does not cause significant histological changes in the kidneys, liver, or brain cortex. these findings should be re-evaluated in additional long-term studies. background monosodium glutamate (msg) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of msg has been shown to ...

aim: we conducted this study to investigate the role of ramadan fasting on oxidative stress. materials and method: 23 people (16 male, 7 female) aged between 25 and 65 years were recruited in this study. 10cc venous blood samples were taken after 8- to 10- hours fasting on 2 different times: a week before ramadan and at the end of ramadan (day 27). portions of the serum samples were used immedi...

conclusions it may be concluded that combination of losartan with higher dose of va decreases ischemic markers and lipid peroxidation and augments endogenous antioxidant and hence, protects myocardium against i/r-induced oxidative stress injuries. results there was a more significant decrease in the levels of ldh, cpk, ck-mb, and mda as well as increase in the levels of sod, cat and gpx in grou...