We reported that an 11 amino acid synthetic peptide (P1) activates lung endothelial cell nitric oxide synthase (eNOS) independent of its change in expression and/or phosphorylation. Since caveolae/eNOS dissociation is known to enhance the catalytic activity of eNOS, we examined whether P1-mediated increase of eNOS activity is associated with caveolae/cholesterol modulation, increased caveolin-1...

To identify determinants of attenuation in the poliovirus type 1 Sabin vaccine strain, a series of recombinant viruses were constructed by using infectious cDNA clones of the virulent type 1 poliovirus P1/Mahoney and the attenuated type 1 vaccine strain P1/Sabin. Intracerebral inoculation of these viruses into transgenic mice which express the human receptor for poliovirus identified regions of...

WF activity STS description WebServiceInput(a?(p1:t1)) ifElse (((p1 < 10), WebServiceOutput(b!(p2:t2))), ((p1 10), WebServiceOutput(c!(p3:t3))) ) ... ... listen( EventDriven (WebServiceInput(b?(p2:t2)),...), EventDriven (WebServiceInput(c?(p3:t3)),...), EventDriven(Delay,...) ) t a u

Conditions are established on a polynomial f in two variables under which the equality f(P1, P2) = 0 for two orthogonal projections P1, P2 is possible only if P1 and P2 commute.

Abstract Background Mycoplasma pneumoniae (MP), a common pediatric pneumonia pathogen, has 2 subtypes based on P1 adhesin gene variation. Macrolide-resistant MP (MRMP), seen since 2000 in many countries, been subtype associated. Limited U.S. data exist or MRMP frequency and their clinical importance. Methods During 2015–2020, mid-turbinate nasal swab (MTNS) specimens and/or throat swabs were co...

Tomato ringspot nepovirus RNA-1-encoded polyprotein (P1) contains the domains for the putative NTP-binding protein, VPg, 3C-like protease and a putative RNA-dependent RNA polymerase in its C-terminal region. The N-terminal region of P1, with a coding capacity for a protein (or a precursor) of 67 kDa, has not been characterized. Using partial cDNA clones, it is shown that the 3C-like protease ca...