Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy. Recent studies have discovered pivotal role of the intratumoral microbiota in various cancers, yet it remains elusive ACC. Here, we explored microbiome data derived from silico identification, further validated an in-house cohort by bacterial 16S rRNA fluorescence situ hybridization and lipopolysaccharide staining. Unsupervised...

Methylmalonic acidemia (MMA) is widely considered as an autosomal recessive metabolic disorder that results in accumulation of high levels of methylmalonic acid and eventually brain damage. This study aims to investigate the effects of methylmalonic acid on neurons and analyze various gene expression profiles in rat cortical neurons treated with methylmalonic acid in order to understand the eff...

type p53 is normally expressed at low levels and inactive due to the action of MDM2, an E3 ubiquitin ligase that binds p53 and promotes its degradation [1, 2]. However, p53 is stabilized in response to various stresses, such as DNA damage or inappropriate oncogene signaling, that might otherwise predispose a normal cell toward tumorigenesis [3]. The stress-induced stabilization of p53 results f...

Defects in p53 and nuclear factor-kappa B (NF-κB) signaling pathways are frequently observed in the initiation and development of various human malignancies, including prostate cancer. Clinical studies demonstrate higher expression of NF-κB/p65/RelA, NF-κB/p50/RelB, and cRel as well as downregulation of the p53 network in primary prostate cancer specimens and in metastatic tumors. Betulinic aci...

Previous findings suggest an angiogenesis-regulating function of the p53 tumor suppressor protein in various malignancies. With several antiangiogenic agents entering the clinic, we assessed the value of the TP53 status in predicting angiogenesis in glioblastoma in vivo and examined underlying angiogenic-signaling pathways in vitro. We identified 26 TP53 wild-type and 9 TP53 mutated treatment-n...

morphology and other phenotypic features characteristic of cellular senescence can be triggered by telomere attrition (replicative senescence) and various stresses such as activated oncogenes or genotoxic treatments (premature senescence). Physiological relevance of cellular senescence is apparent from its emerging roles in aging, in tumor pathogenesis as an inducible barrier to tumor progressi...