OBJECTIVE The purpose of this study was to evaluate whether routine prostate MRI is adequate for detection of bone metastasis in patients with newly diagnosed prostate cancer. MATERIALS AND METHODS The study included 308 patients with newly diagnosed prostate cancer who underwent prostate MRI. Two radiologists categorized MRI findings as normal, metastasis, or equivocal. Histologic analysis o...

Suppression of bone metastasis can improve patient quality of life. Current drugs for bone metastasis have been shown to prolong progression-free survival but not overall survival; therefore, other potential therapeutic targets for bone metastasis should be investigated. Cell-surface antigens, such as CD24, have been recently shown to be involved in the metastasis of various cancers. However, w...

Abstract Background Prostate cancers frequently metastasize to bone, where the best microenvironment for distant colonization is provided. Since osteotropic metastasis of prostate cancer a critical determinant patients’ survival, searches preventive measures are ongoing in field. Therefore, it important dissect mechanisms each step bone metastasis, including epithelial-mesenchymal transition (E...

Since breast cancer is frequently associated with bone metastasis, bone scintigraphies have been performed to determine pre-operative staging and to survey postoperative bone metastasis. The sternum, in particular, is a site at which is difficult to differentiate between benign bone disease and bone metastasis, because of varied uptake and wide individual variations. In this study, chronologica...

introduction:the use of beta emitters is one of the effective methods for palliation of bone metastasis. the risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. methods: in this study, the monte carlo simulation code mcnpx was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. specific absorbed fractions were calculated...

OBJECTIVE We report a rare case of malignant priapism secondary to transitional cell carcinoma. METHODS The patient with bladder cancer (pT4G3) presented with painful penile erection. Corpora cavernosa biopsy was done. RESULTS The pathologic diagnosis was penile metastasis of transitional cell carcinoma. CONCLUSIONS Priapism secondary to penile metastasis of transitional cell carcinoma is...

BACKGROUND Analyses of phase III trials showed that denosumab was superior to zoledronic acid (ZA) in preventing skeletal-related events (SREs) irrespective of age, history of SREs, or baseline pain status. This analysis assessed the risk of SREs across additional baseline characteristics. PATIENTS AND METHODS Patients (N = 5543) from three phase III trials who had breast cancer, prostate can...

Bone metastasis is common in lung cancer patient and the diagnosis of bone metastasis is usually made by using imaging techniques, especially bone scintigraphy. However, the diagnostic yield from bone scintigraphy is limited. The aim of this study is to assess the clinical usefulness of urinary pyridinoline cross-linked N-telopeptides of Type I collagen (NTx), urinary deoxypyridinoline (DPD), a...

OBJECTIVE To investigate the quality of life (QOL) following palliative radiotherapy for painful bone metastases. METHODS A literature search was conducted in OvidSP Medline (1946-Jan Week 4 2014), Embase (1947-Week 5 2014), and the Cochrane Central Register of Controlled Trials (Dec 2013) databases. The search was limited to English. Subject headings and keywords included 'palliative radiati...

Bone metastasis greatly deteriorates the quality of life in patients with cancer. Although mechanisms have been widely investigated, the relationship between cancer bone metastasis and antitumor immunity in the host has been much less studied. Here, we report a novel mechanism of bone metastasis mediated by FSTL1, a follistatin-like glycoprotein secreted by Snail(+) tumor cells, which metastasi...